Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2684615..2685242 Replicon chromosome
Accession NZ_CP104022
Organism Erwinia amylovora strain Ea102

Toxin (Protein)


Gene name Hha Uniprot ID D2T444
Locus tag MTP49_RS12115 Protein ID WP_004156337.1
Coordinates 2685024..2685242 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag MTP49_RS12110 Protein ID WP_013035913.1
Coordinates 2684615..2685004 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP49_RS12090 (MTP49_12090) 2679634..2682780 + 3147 WP_004156353.1 multidrug efflux RND transporter permease subunit AcrB -
MTP49_RS12095 (MTP49_12095) 2682928..2683209 + 282 WP_004156350.1 type B 50S ribosomal protein L31 -
MTP49_RS12100 (MTP49_12100) 2683197..2683343 + 147 WP_004156349.1 type B 50S ribosomal protein L36 -
MTP49_RS12105 (MTP49_12105) 2684115..2684468 + 354 WP_004156342.1 hypothetical protein -
MTP49_RS12110 (MTP49_12110) 2684615..2685004 + 390 WP_013035913.1 Hha toxicity modulator TomB Antitoxin
MTP49_RS12115 (MTP49_12115) 2685024..2685242 + 219 WP_004156337.1 HHA domain-containing protein Toxin
MTP49_RS12125 (MTP49_12125) 2685542..2685859 + 318 WP_168397246.1 MGMT family protein -
MTP49_RS12130 (MTP49_12130) 2685882..2686439 - 558 WP_004156333.1 YbaY family lipoprotein -
MTP49_RS12135 (MTP49_12135) 2686664..2687524 + 861 WP_004156324.1 acyl-CoA thioesterase II -
MTP49_RS12140 (MTP49_12140) 2687599..2688900 - 1302 WP_004172214.1 ammonium transporter AmtB -
MTP49_RS12145 (MTP49_12145) 2688918..2689256 - 339 WP_004156319.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8627.06 Da        Isoelectric Point: 8.9007

>T257029 WP_004156337.1 NZ_CP104022:2685024-2685242 [Erwinia amylovora]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 14965.70 Da        Isoelectric Point: 4.7040

>AT257029 WP_013035913.1 NZ_CP104022:2684615-2685004 [Erwinia amylovora]
MDEYSPKRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSTSNLQLNDLIEHIAAFTMNYKIKHIEDSDLISQIDEYL
DDTFMLFSNYGVNNLDLQRWQKSAKRLFNIFAKECVMSQIQSSHSFSSP

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPQ0

Antitoxin

Source ID Structure

References