Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 180508..181146 Replicon chromosome
Accession NZ_CP103972
Organism Escherichia coli strain DLI.5a

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NZD79_RS00875 Protein ID WP_000813794.1
Coordinates 180508..180684 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NZD79_RS00880 Protein ID WP_001270286.1
Coordinates 180730..181146 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NZD79_RS00855 (176127) 176127..177302 - 1176 WP_001236265.1 BenE family transporter YdcO -
NZD79_RS00860 (177394) 177394..177930 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NZD79_RS00865 (178003) 178003..179964 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NZD79_RS00870 (180056) 180056..180286 - 231 WP_000494244.1 YncJ family protein -
NZD79_RS00875 (180508) 180508..180684 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NZD79_RS00880 (180730) 180730..181146 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NZD79_RS00885 (181225) 181225..182631 + 1407 WP_259568179.1 PLP-dependent aminotransferase family protein -
NZD79_RS00890 (182876) 182876..184021 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
NZD79_RS00895 (184039) 184039..185052 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NZD79_RS00900 (185053) 185053..185994 + 942 WP_097342115.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T256917 WP_000813794.1 NZ_CP103972:180508-180684 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT256917 WP_001270286.1 NZ_CP103972:180730-181146 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References