Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 2295296..2295938 Replicon chromosome
Accession NZ_CP103832
Organism Actinobacillus equuli subsp. haemolyticus strain 798

Toxin (Protein)


Gene name higB Uniprot ID K0GF68
Locus tag NYR88_RS10805 Protein ID WP_005621659.1
Coordinates 2295296..2295667 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NYR88_RS10810 Protein ID WP_039198813.1
Coordinates 2295648..2295938 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR88_RS10790 (NYR88_10790) 2291802..2292656 + 855 WP_279444366.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
NYR88_RS10795 (NYR88_10795) 2292700..2293269 - 570 WP_279441422.1 elongation factor P hydroxylase -
NYR88_RS10800 (NYR88_10800) 2293328..2295076 - 1749 WP_279444367.1 protein-disulfide reductase DsbD -
NYR88_RS10805 (NYR88_10805) 2295296..2295667 + 372 WP_005621659.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR88_RS10810 (NYR88_10810) 2295648..2295938 + 291 WP_039198813.1 helix-turn-helix transcriptional regulator Antitoxin
NYR88_RS10815 (NYR88_10815) 2296006..2296968 - 963 WP_279442035.1 calcium/sodium antiporter -
NYR88_RS10820 (NYR88_10820) 2297041..2297538 + 498 WP_015674483.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
NYR88_RS10825 (NYR88_10825) 2297762..2298496 + 735 WP_279444368.1 arginine ABC transporter ATP-binding protein ArtP -
NYR88_RS10830 (NYR88_10830) 2298516..2299235 + 720 WP_279444369.1 transporter substrate-binding domain-containing protein -
NYR88_RS10835 (NYR88_10835) 2299241..2299912 + 672 WP_279444370.1 arginine ABC transporter permease ArtQ -
NYR88_RS10840 (NYR88_10840) 2299912..2300596 + 685 Protein_2082 arginine ABC transporter permease ArtM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(33-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-85)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14938.10 Da        Isoelectric Point: 9.5717

>T256775 WP_005621659.1 NZ_CP103832:2295296-2295667 [Actinobacillus equuli subsp. haemolyticus]
MYEIVFYRDRRGREPVKEFLQEFINEQQDENRERLHKISHHLTILHLHGTRAGESYIKHLEDRIWQLRPISDCLLFAGIV
RGQFVLLHHFAKSSSRLPKRELERAKSRLADLQERIKDEPHWF

Download         Length: 372 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10821.59 Da        Isoelectric Point: 8.7275

>AT256775 WP_039198813.1 NZ_CP103832:2295648-2295938 [Actinobacillus equuli subsp. haemolyticus]
MSPIGSSWTSFEREVFNELEMEENHFRVKLILEIIETRQALGISQRKLEKLSGVKQSMIARIEKGSSNPSLGTLLKLLVP
LGKTLQIVSLDETHSK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A7MI46

Antitoxin

Source ID Structure

References