Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1883845..1884959 Replicon chromosome
Accession NZ_CP103832
Organism Actinobacillus equuli subsp. haemolyticus strain 798

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NYR88_RS08755 Protein ID WP_279445004.1
Coordinates 1884171..1884959 (-) Length 263 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A3N2X7
Locus tag NYR88_RS08750 Protein ID WP_005613259.1
Coordinates 1883845..1884174 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR88_RS08740 (NYR88_08740) 1880772..1882052 + 1281 WP_279444174.1 threonine synthase -
NYR88_RS08745 (NYR88_08745) 1882193..1883516 - 1324 Protein_1690 MFS transporter family glucose-6-phosphate receptor UhpC -
NYR88_RS08750 (NYR88_08750) 1883845..1884174 - 330 WP_005613259.1 helix-turn-helix domain-containing protein Antitoxin
NYR88_RS08755 (NYR88_08755) 1884171..1884959 - 789 WP_279445004.1 HipA domain-containing protein Toxin
NYR88_RS08760 (NYR88_08760) 1884941..1885501 - 561 WP_279444175.1 hypothetical protein -
NYR88_RS08765 (NYR88_08765) 1885903..1886934 + 1032 WP_279444176.1 Abi family protein -
NYR88_RS08770 (NYR88_08770) 1887124..1888665 - 1542 WP_279444177.1 NACHT domain-containing protein -
NYR88_RS08775 (NYR88_08775) 1888649..1888981 - 333 WP_279444178.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(11-186)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-94)


Sequences

Toxin        


Download         Length: 263 a.a.        Molecular weight: 30595.60 Da        Isoelectric Point: 4.9464

>T256772 WP_279445004.1 NZ_CP103832:c1884959-1884171 [Actinobacillus equuli subsp. haemolyticus]
IDNLQLGLDCDTAYLVKYPRGNYSELDCDILRAEYHYYHELRALGFSTIDTDLMKLEEGERYPSLWLPRFDMKFKDGKWE
RYAMESVYSMLQKYGGNLDHDQTIRNLLNVISASQFSNDFDNRHFVIEWVKRDLLNIAFGNSDNHGRNTAFLRDDNRIWL
SPIYDFAPMRADPEGIIRTTTWAKNGDTPQEFAGEYRFDKIADGLSDLIEPDILLRELRMLATQLVDLKSRLTKRGVPKS
ILDFPAIGFDYLPEKLQRWGSV

Download         Length: 789 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12320.45 Da        Isoelectric Point: 10.8292

>AT256772 WP_005613259.1 NZ_CP103832:c1884174-1883845 [Actinobacillus equuli subsp. haemolyticus]
MTIQHKNASPTRSKVNGIERQLIRETIIVQLLKGEISQGQALRRLRVEALGINQQDYLKLAKVSRQTLSNIENDKGNYSI
ETINQVFKPMGLKLGLMPISKDLMASFLK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A3N2X7

References