Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1601265..1601919 Replicon chromosome
Accession NZ_CP103819
Organism Actinobacillus equuli subsp. haemolyticus strain 3873

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR74_RS07445 Protein ID WP_278226473.1
Coordinates 1601557..1601919 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR74_RS07440 Protein ID WP_279453291.1
Coordinates 1601265..1601573 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR74_RS07415 (NYR74_07415) 1596410..1596976 - 567 WP_039198375.1 septal ring lytic transglycosylase RlpA family protein -
NYR74_RS07420 (NYR74_07420) 1597151..1598275 - 1125 WP_279453294.1 rod shape-determining protein RodA -
NYR74_RS07425 (NYR74_07425) 1598268..1600238 - 1971 WP_279453293.1 penicillin-binding protein 2 -
NYR74_RS07430 (NYR74_07430) 1600321..1600788 - 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR74_RS07435 (NYR74_07435) 1600811..1601125 - 315 WP_279453292.1 ribosome silencing factor -
NYR74_RS07440 (NYR74_07440) 1601265..1601573 - 309 WP_279453291.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR74_RS07445 (NYR74_07445) 1601557..1601919 - 363 WP_278226473.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR74_RS07450 (NYR74_07450) 1602101..1604695 - 2595 WP_279453290.1 DNA mismatch repair protein MutS -
NYR74_RS07455 (NYR74_07455) 1604862..1605611 - 750 WP_279453289.1 amino acid ABC transporter ATP-binding protein -
NYR74_RS07460 (NYR74_07460) 1605633..1606349 - 717 WP_005605560.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-86)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14067.13 Da        Isoelectric Point: 10.1215

>T256733 WP_278226473.1 NZ_CP103819:c1601919-1601557 [Actinobacillus equuli subsp. haemolyticus]
VKLVFVELPPFERYRQKHLSDEEYRHFQNELLENPNKGDLIQGTNGLRKIRIADMQRNKGKRGGARVIYYHIVNYSKILL
VTAYGKDEQSDLSNTERNMLANKVKRIVELEIRSCNGKTF

Download         Length: 363 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.52 Da        Isoelectric Point: 8.5450

>AT256733 WP_279453291.1 NZ_CP103819:c1601573-1601265 [Actinobacillus equuli subsp. haemolyticus]
MGKLFDDLMEGLDAYEKHIQGKITLRTTVLEKPEPVELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QAVLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References