Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1977397..1978047 Replicon chromosome
Accession NZ_CP103817
Organism Actinobacillus equuli subsp. equuli strain 4005

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYR71_RS09035 Protein ID WP_279439544.1
Coordinates 1977397..1977738 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYR71_RS09040 Protein ID WP_279439545.1
Coordinates 1977739..1978047 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYR71_RS09020 (NYR71_09020) 1972968..1973684 + 717 WP_005605560.1 amino acid ABC transporter permease -
NYR71_RS09025 (NYR71_09025) 1973706..1974455 + 750 WP_279439542.1 amino acid ABC transporter ATP-binding protein -
NYR71_RS09030 (NYR71_09030) 1974621..1977215 + 2595 WP_279439543.1 DNA mismatch repair protein MutS -
NYR71_RS09035 (NYR71_09035) 1977397..1977738 + 342 WP_279439544.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYR71_RS09040 (NYR71_09040) 1977739..1978047 + 309 WP_279439545.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
NYR71_RS09045 (NYR71_09045) 1978187..1978501 + 315 WP_005619625.1 ribosome silencing factor -
NYR71_RS09050 (NYR71_09050) 1978524..1978991 + 468 WP_005598965.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
NYR71_RS09055 (NYR71_09055) 1979074..1981044 + 1971 WP_279439546.1 penicillin-binding protein 2 -
NYR71_RS09060 (NYR71_09060) 1981037..1982161 + 1125 WP_039198374.1 rod shape-determining protein RodA -
NYR71_RS09065 (NYR71_09065) 1982336..1982902 + 567 WP_039198375.1 septal ring lytic transglycosylase RlpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(46-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-80)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13344.27 Da        Isoelectric Point: 9.8646

>T256723 WP_279439544.1 NZ_CP103817:1977397-1977738 [Actinobacillus equuli subsp. equuli]
VKLVFVELPPFDKFRYENLTDDDYREFQEYLMNNPEAGDIVQGVNGLRKIRISTQAKGKKGGARVIYYYYVRGSQIWLFT
GYNKSRKIDLNSMERRAFSKVLEHLKNIADREL

Download         Length: 342 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11618.45 Da        Isoelectric Point: 7.2032

>AT256723 WP_279439545.1 NZ_CP103817:1977739-1978047 [Actinobacillus equuli subsp. equuli]
MGRLFDDLMEGAEALEQYLQGKITLRTTVLEKPEPIELSPSEVKSIREKLNLSQAVFAHKLHTSVRTYQGWEQGKTKPNP
QATLLLRMVDKSPQLLEQMAQL

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References