Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 301649..302162 Replicon chromosome
Accession NC_016050
Organism Rickettsia japonica YH

Toxin (Protein)


Gene name yoeB Uniprot ID G4KME1
Locus tag RJP_RS01565 Protein ID WP_014120591.1
Coordinates 301902..302162 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0F3RGJ3
Locus tag RJP_RS01560 Protein ID WP_014013992.1
Coordinates 301649..301891 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RJP_RS01540 296676..298445 - 1770 WP_014120587.1 ABC transporter ATP-binding protein/permease -
RJP_RS01545 298626..298895 + 270 WP_014013989.1 DUF2671 domain-containing protein -
RJP_RS01550 299050..300420 + 1371 WP_014120588.1 cytochrome ubiquinol oxidase subunit I -
RJP_RS01555 300428..301447 + 1020 WP_014120589.1 cytochrome d ubiquinol oxidase subunit II -
RJP_RS01560 301649..301891 + 243 WP_014013992.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RJP_RS01565 301902..302162 + 261 WP_014120591.1 Txe/YoeB family addiction module toxin Toxin
RJP_RS01570 302155..303003 + 849 WP_014120592.1 glycosyltransferase family 2 protein -
RJP_RS01575 303080..304318 + 1239 WP_014120593.1 insulinase family protein -
RJP_RS01580 304472..305182 + 711 WP_014120594.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
RJP_RS01585 305411..306997 + 1587 WP_014120595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10254.07 Da        Isoelectric Point: 9.8788

>T25661 WP_014120591.1 NC_016050:301902-302162 [Rickettsia japonica YH]
MYIIRYTTQAQKDAKKIVQAGLKNKVEVLLNIVSTDPWKIYPPYEKLVGDFSGCYSRRINIQHRLVCEVYKQEKVVKILR
MYTHYE

Download         Length: 261 bp

>T25661 NC_016050:301902-302162 [Rickettsia japonica YH]
ATGTATATAATTCGTTATACTACACAAGCACAAAAAGATGCTAAGAAAATAGTGCAAGCCGGTTTAAAGAATAAAGTAGA
AGTTTTATTAAACATAGTTAGTACTGATCCTTGGAAAATTTACCCTCCATATGAAAAGCTCGTTGGTGACTTTAGCGGTT
GTTATTCAAGAAGAATTAATATTCAACATAGGTTGGTTTGTGAAGTTTACAAACAAGAAAAAGTTGTAAAAATTCTTAGA
ATGTATACGCATTATGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9405.83 Da        Isoelectric Point: 7.1617

>AT25661 WP_014013992.1 NC_016050:301649-301891 [Rickettsia japonica YH]
MEIYNTSEARSKLYKLIDYVSDVHKPVYIKGKRNNVVIISEEDYRNMEETLYLLSIPNMHKSLIEGRAEPIAKCSDKLNW

Download         Length: 243 bp

>AT25661 NC_016050:301649-301891 [Rickettsia japonica YH]
ATGGAAATATATAATACAAGCGAAGCAAGAAGTAAGCTTTATAAACTTATAGATTATGTTTCTGATGTACACAAACCTGT
TTATATTAAAGGTAAAAGAAATAATGTAGTTATAATTTCAGAAGAAGATTATCGTAATATGGAAGAAACTTTATATTTAT
TATCTATTCCAAATATGCATAAGTCTCTAATTGAAGGACGAGCAGAGCCTATAGCAAAGTGTAGCGATAAATTAAATTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3B7DC01

Antitoxin

Source ID Structure
AlphaFold DB A0A0F3RGJ3

References