Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 750694..751529 Replicon chromosome
Accession NZ_CP103739
Organism Escherichia coli strain 3359

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J2AEA6
Locus tag M5T33_RS03665 Protein ID WP_000854759.1
Coordinates 751152..751529 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag M5T33_RS03660 Protein ID WP_001295723.1
Coordinates 750694..751062 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T33_RS03630 (747812) 747812..748007 + 196 Protein_696 DUF905 family protein -
M5T33_RS03635 (748125) 748125..748943 + 819 WP_044810630.1 DUF932 domain-containing protein -
M5T33_RS03640 (748943) 748943..749188 + 246 WP_000680586.1 hypothetical protein -
M5T33_RS03645 (749282) 749282..749755 + 474 WP_044810631.1 antirestriction protein -
M5T33_RS03650 (749771) 749771..750247 + 477 WP_001186775.1 RadC family protein -
M5T33_RS03655 (750310) 750310..750531 + 222 WP_000692345.1 DUF987 domain-containing protein -
M5T33_RS03660 (750694) 750694..751062 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M5T33_RS03665 (751152) 751152..751529 + 378 WP_000854759.1 TA system toxin CbtA family protein Toxin
M5T33_RS03670 (751526) 751526..752053 + 528 WP_259431154.1 DUF5983 family protein -
M5T33_RS03680 (753367) 753367..753543 + 177 WP_000839286.1 DUF957 domain-containing protein -
M5T33_RS03685 (753649) 753649..753798 + 150 Protein_707 hypothetical protein -
M5T33_RS03690 (754165) 754165..754341 + 177 Protein_708 helix-turn-helix domain-containing protein -
M5T33_RS03695 (754605) 754605..754832 + 228 WP_024183600.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 679611..764444 84833


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14144.26 Da        Isoelectric Point: 7.3249

>T256422 WP_000854759.1 NZ_CP103739:751152-751529 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDLPGF
SACTHSQLINSIDILRARRATGLMIRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT256422 WP_001295723.1 NZ_CP103739:750694-751062 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2AEA6

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References