Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 842365..843019 Replicon chromosome
Accession NZ_CP103710
Organism Escherichia coli O25b:H4-ST131

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag M5S69_RS04190 Protein ID WP_000244765.1
Coordinates 842612..843019 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag M5S69_RS04185 Protein ID WP_000354050.1
Coordinates 842365..842631 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S69_RS04165 (838453) 838453..839886 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
M5S69_RS04170 (839931) 839931..840242 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
M5S69_RS04175 (840406) 840406..841065 + 660 WP_000250275.1 hemolysin III family protein -
M5S69_RS04180 (841142) 841142..842122 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
M5S69_RS04185 (842365) 842365..842631 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
M5S69_RS04190 (842612) 842612..843019 + 408 WP_000244765.1 protein YgfX Toxin
M5S69_RS04195 (843059) 843059..843580 - 522 WP_001055874.1 flavodoxin FldB -
M5S69_RS04200 (843692) 843692..844588 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5S69_RS04205 (844613) 844613..845323 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5S69_RS04210 (845329) 845329..847062 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T256278 WP_000244765.1 NZ_CP103710:842612-843019 [Escherichia coli O25b:H4-ST131]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT256278 WP_000354050.1 NZ_CP103710:842365-842631 [Escherichia coli O25b:H4-ST131]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References