Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3442639..3443257 Replicon chromosome
Accession NZ_CP103694
Organism Escherichia coli strain ST12468

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5T31_RS16945 Protein ID WP_001291435.1
Coordinates 3443039..3443257 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5T31_RS16940 Protein ID WP_000344800.1
Coordinates 3442639..3443013 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T31_RS16930 (3437728) 3437728..3438921 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5T31_RS16935 (3438944) 3438944..3442093 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M5T31_RS16940 (3442639) 3442639..3443013 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5T31_RS16945 (3443039) 3443039..3443257 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5T31_RS16950 (3443429) 3443429..3443980 + 552 WP_000102564.1 maltose O-acetyltransferase -
M5T31_RS16955 (3444096) 3444096..3444566 + 471 WP_000136192.1 YlaC family protein -
M5T31_RS16960 (3444730) 3444730..3446280 + 1551 WP_023281027.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5T31_RS16965 (3446322) 3446322..3446675 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M5T31_RS16975 (3447054) 3447054..3447365 + 312 WP_000409911.1 MGMT family protein -
M5T31_RS16980 (3447396) 3447396..3447968 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T256207 WP_001291435.1 NZ_CP103694:3443039-3443257 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT256207 WP_000344800.1 NZ_CP103694:3442639-3443013 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References