Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4921184..4922865 Replicon chromosome
Accession NZ_CP103614
Organism Klebsiella pneumoniae strain 3571

Toxin (Protein)


Gene name mosT Uniprot ID J2XCI1
Locus tag M5T29_RS23960 Protein ID WP_004146663.1
Coordinates 4921184..4922101 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag M5T29_RS23965 Protein ID WP_004177809.1
Coordinates 4922107..4922865 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T29_RS23940 (M5T29_23940) 4916490..4918010 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
M5T29_RS23945 (M5T29_23945) 4918007..4919005 + 999 WP_004872882.1 ribose ABC transporter permease -
M5T29_RS23950 (M5T29_23950) 4919036..4919977 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
M5T29_RS23955 (M5T29_23955) 4920052..4921059 + 1008 WP_004177805.1 carbohydrate kinase family protein -
M5T29_RS23960 (M5T29_23960) 4921184..4922101 - 918 WP_004146663.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M5T29_RS23965 (M5T29_23965) 4922107..4922865 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
M5T29_RS23970 (M5T29_23970) 4922951..4923679 - 729 WP_004177810.1 response regulator transcription factor -
M5T29_RS23975 (M5T29_23975) 4923952..4926099 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
M5T29_RS23980 (M5T29_23980) 4926096..4926239 - 144 WP_022631365.1 hypothetical protein -
M5T29_RS23985 (M5T29_23985) 4926445..4927131 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34659.10 Da        Isoelectric Point: 5.4707

>T255837 WP_004146663.1 NZ_CP103614:c4922101-4921184 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT255837 WP_004177809.1 NZ_CP103614:c4922865-4922107 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J2XCI1

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References