Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2568236..2569824 Replicon chromosome
Accession NZ_CP103579
Organism Klebsiella pneumoniae strain 4014

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag M5S61_RS12665 Protein ID WP_002904792.1
Coordinates 2568236..2569558 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag M5S61_RS12670 Protein ID WP_002904790.1
Coordinates 2569558..2569824 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S61_RS12655 (2565669) 2565669..2566673 + 1005 WP_009308876.1 fimbrial protein -
M5S61_RS12660 (2566927) 2566927..2568219 + 1293 WP_032423495.1 glycoside hydrolase family 10 protein -
M5S61_RS12665 (2568236) 2568236..2569558 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
M5S61_RS12670 (2569558) 2569558..2569824 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5S61_RS12675 (2570211) 2570211..2570537 - 327 WP_002904788.1 hydroxyisourate hydrolase -
M5S61_RS12680 (2570534) 2570534..2571034 - 501 WP_032446037.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
M5S61_RS12685 (2571012) 2571012..2572391 - 1380 WP_071081018.1 nucleobase:cation symporter-2 family protein -
M5S61_RS12690 (2572737) 2572737..2573891 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
M5S61_RS12695 (2573872) 2573872..2574795 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T255652 WP_002904792.1 NZ_CP103579:c2569558-2568236 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT255652 WP_002904790.1 NZ_CP103579:c2569824-2569558 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References