Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 994977..995631 Replicon chromosome
Accession NZ_CP103562
Organism Escherichia coli O25b:H4-ST131 strain 751

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag M5R24_RS04945 Protein ID WP_000244765.1
Coordinates 995224..995631 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag M5R24_RS04940 Protein ID WP_000354050.1
Coordinates 994977..995243 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5R24_RS04920 (991065) 991065..992498 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
M5R24_RS04925 (992543) 992543..992854 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
M5R24_RS04930 (993018) 993018..993677 + 660 WP_000250275.1 hemolysin III family protein -
M5R24_RS04935 (993754) 993754..994734 - 981 WP_000886084.1 tRNA-modifying protein YgfZ -
M5R24_RS04940 (994977) 994977..995243 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
M5R24_RS04945 (995224) 995224..995631 + 408 WP_000244765.1 protein YgfX Toxin
M5R24_RS04950 (995671) 995671..996192 - 522 WP_001055874.1 flavodoxin FldB -
M5R24_RS04955 (996304) 996304..997200 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5R24_RS04960 (997225) 997225..997935 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5R24_RS04965 (997941) 997941..999674 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T255561 WP_000244765.1 NZ_CP103562:995224-995631 [Escherichia coli O25b:H4-ST131]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT255561 WP_000354050.1 NZ_CP103562:994977-995243 [Escherichia coli O25b:H4-ST131]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References