Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2402410..2403048 Replicon chromosome
Accession NZ_CP103515
Organism Escherichia coli strain 5444

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag M5S96_RS11730 Protein ID WP_001447010.1
Coordinates 2402872..2403048 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5S96_RS11725 Protein ID WP_001270286.1
Coordinates 2402410..2402826 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S96_RS11705 (2397562) 2397562..2398503 - 942 WP_001251304.1 ABC transporter permease -
M5S96_RS11710 (2398504) 2398504..2399517 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
M5S96_RS11715 (2399535) 2399535..2400680 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
M5S96_RS11720 (2400925) 2400925..2402331 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
M5S96_RS11725 (2402410) 2402410..2402826 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M5S96_RS11730 (2402872) 2402872..2403048 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M5S96_RS11735 (2403270) 2403270..2403500 + 231 WP_000494244.1 YncJ family protein -
M5S96_RS11740 (2403592) 2403592..2405553 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M5S96_RS11745 (2405626) 2405626..2406162 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
M5S96_RS11750 (2406254) 2406254..2407429 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2407469..2408617 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T255273 WP_001447010.1 NZ_CP103515:c2403048-2402872 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT255273 WP_001270286.1 NZ_CP103515:c2402826-2402410 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References