Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4335346..4335604 Replicon chromosome
Accession NZ_CP103479
Organism Escherichia coli strain 4621

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag M5T46_RS20610 Protein ID WP_000809168.1
Coordinates 4335452..4335604 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4335346..4335403 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T46_RS20595 4331738..4332697 + 960 WP_000871677.1 hypothetical protein -
M5T46_RS20600 4332735..4333634 - 900 WP_001300855.1 transcriptional activator NhaR -
M5T46_RS20605 4333700..4334866 - 1167 WP_000681352.1 Na+/H+ antiporter NhaA -
- 4335346..4335403 - 58 - - Antitoxin
M5T46_RS20610 4335452..4335604 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
M5T46_RS20615 4335708..4336838 - 1131 WP_001118464.1 molecular chaperone DnaJ -
M5T46_RS20620 4336927..4338843 - 1917 WP_000516135.1 molecular chaperone DnaK -
M5T46_RS20625 4339219..4339623 + 405 WP_000843582.1 DUF2541 family protein -
M5T46_RS20630 4339649..4340362 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T255141 WP_000809168.1 NZ_CP103479:4335452-4335604 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT255141 NZ_CP103479:c4335403-4335346 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References