Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 949630..950284 Replicon chromosome
Accession NZ_CP103465
Organism Escherichia coli O25b:H4-ST131 strain 5392

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag M5T42_RS04700 Protein ID WP_000244765.1
Coordinates 949877..950284 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag M5T42_RS04695 Protein ID WP_000354050.1
Coordinates 949630..949896 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T42_RS04675 (945718) 945718..947151 - 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -
M5T42_RS04680 (947196) 947196..947507 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
M5T42_RS04685 (947671) 947671..948330 + 660 WP_000250275.1 hemolysin III family protein -
M5T42_RS04690 (948407) 948407..949387 - 981 WP_000886080.1 tRNA-modifying protein YgfZ -
M5T42_RS04695 (949630) 949630..949896 + 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
M5T42_RS04700 (949877) 949877..950284 + 408 WP_000244765.1 protein YgfX Toxin
M5T42_RS04705 (950324) 950324..950845 - 522 WP_001055874.1 flavodoxin FldB -
M5T42_RS04710 (950957) 950957..951853 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
M5T42_RS04715 (951878) 951878..952588 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T42_RS04720 (952594) 952594..954327 + 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T255076 WP_000244765.1 NZ_CP103465:949877-950284 [Escherichia coli O25b:H4-ST131]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT255076 WP_000354050.1 NZ_CP103465:949630-949896 [Escherichia coli O25b:H4-ST131]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References