Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3542594..3543110 Replicon chromosome
Accession NZ_CP103445
Organism Erwinia pyrifoliae strain CP201486

Toxin (Protein)


Gene name relE Uniprot ID D2T7S6
Locus tag NYP84_RS16775 Protein ID WP_012669379.1
Coordinates 3542826..3543110 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D2T7S5
Locus tag NYP84_RS16770 Protein ID WP_012669378.1
Coordinates 3542594..3542836 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP84_RS16755 (NYP84_16755) 3537911..3538273 - 363 WP_226060675.1 helix-turn-helix transcriptional regulator -
NYP84_RS16760 (NYP84_16760) 3538376..3541063 + 2688 WP_259825859.1 CHC2 zinc finger domain-containing protein -
NYP84_RS16765 (NYP84_16765) 3541278..3542333 + 1056 WP_012669377.1 site-specific tyrosine recombinase XerC -
NYP84_RS16770 (NYP84_16770) 3542594..3542836 + 243 WP_012669378.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NYP84_RS16775 (NYP84_16775) 3542826..3543110 + 285 WP_012669379.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYP84_RS16780 (NYP84_16780) 3544177..3545217 + 1041 WP_012666458.1 IS630 family transposase -
NYP84_RS16785 (NYP84_16785) 3545342..3546694 + 1353 WP_012669399.1 adenylate/guanylate cyclase domain-containing protein -
NYP84_RS16790 (NYP84_16790) 3546964..3547368 - 405 WP_012669259.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3496709..3558922 62213
- flank IS/Tn - - 3544177..3545217 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11123.03 Da        Isoelectric Point: 10.3769

>T255054 WP_012669379.1 NZ_CP103445:3542826-3543110 [Erwinia pyrifoliae]
MSYELVFDPRALKEWKKLGATVREQFKKKLAEVLVNPRVESARLREYPDCYKIKLKSSGYRLVYQVQDEQLVVFVVATGK
RERLQVYRDAGKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9070.45 Da        Isoelectric Point: 4.6310

>AT255054 WP_012669378.1 NZ_CP103445:3542594-3542836 [Erwinia pyrifoliae]
MATLNVRLDDKLKSKAYAVLDELDVSPTEAVRLLFQYIAENERLPLKTLTVSDEEDALLKTVRERLASPQKGIRVTLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D2T7S6

Antitoxin

Source ID Structure
AlphaFold DB D2T7S5

References