Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3528578..3529094 Replicon chromosome
Accession NZ_CP103445
Organism Erwinia pyrifoliae strain CP201486

Toxin (Protein)


Gene name relE Uniprot ID D2T7S6
Locus tag NYP84_RS16690 Protein ID WP_012669379.1
Coordinates 3528810..3529094 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D2T7S5
Locus tag NYP84_RS16685 Protein ID WP_012669378.1
Coordinates 3528578..3528820 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP84_RS16670 (NYP84_16670) 3523844..3524248 - 405 WP_259817774.1 helix-turn-helix transcriptional regulator -
NYP84_RS16675 (NYP84_16675) 3524370..3527063 + 2694 WP_259825852.1 CHC2 zinc finger domain-containing protein -
NYP84_RS16680 (NYP84_16680) 3527262..3528317 + 1056 WP_259825854.1 site-specific tyrosine recombinase XerC -
NYP84_RS16685 (NYP84_16685) 3528578..3528820 + 243 WP_012669378.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NYP84_RS16690 (NYP84_16690) 3528810..3529094 + 285 WP_012669379.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYP84_RS16695 (NYP84_16695) 3529586..3529903 + 318 WP_259816732.1 hypothetical protein -
NYP84_RS16700 (NYP84_16700) 3529950..3530372 + 423 WP_226060674.1 hypothetical protein -
NYP84_RS16705 (NYP84_16705) 3530378..3530728 + 351 WP_041474388.1 hypothetical protein -
NYP84_RS16710 (NYP84_16710) 3530785..3531087 - 303 WP_104945003.1 SymE family type I addiction module toxin -
NYP84_RS16715 (NYP84_16715) 3531162..3531524 - 363 WP_226060675.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3496709..3558922 62213


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11123.03 Da        Isoelectric Point: 10.3769

>T255053 WP_012669379.1 NZ_CP103445:3528810-3529094 [Erwinia pyrifoliae]
MSYELVFDPRALKEWKKLGATVREQFKKKLAEVLVNPRVESARLREYPDCYKIKLKSSGYRLVYQVQDEQLVVFVVATGK
RERLQVYRDAGKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9070.45 Da        Isoelectric Point: 4.6310

>AT255053 WP_012669378.1 NZ_CP103445:3528578-3528820 [Erwinia pyrifoliae]
MATLNVRLDDKLKSKAYAVLDELDVSPTEAVRLLFQYIAENERLPLKTLTVSDEEDALLKTVRERLASPQKGIRVTLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D2T7S6

Antitoxin

Source ID Structure
AlphaFold DB D2T7S5

References