Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2845893..2846427 Replicon chromosome
Accession NZ_CP103445
Organism Erwinia pyrifoliae strain CP201486

Toxin (Protein)


Gene name relE Uniprot ID D2T5B9
Locus tag NYP84_RS13440 Protein ID WP_012668982.1
Coordinates 2845893..2846180 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D2T5C0
Locus tag NYP84_RS13445 Protein ID WP_012668983.1
Coordinates 2846185..2846427 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP84_RS13415 (NYP84_13415) 2841211..2842410 - 1200 WP_259825734.1 S-methyl-5-thioribose kinase -
NYP84_RS13420 (NYP84_13420) 2842525..2843556 + 1032 WP_259825735.1 S-methyl-5-thioribose-1-phosphate isomerase -
NYP84_RS13425 (NYP84_13425) 2843607..2844149 - 543 WP_259825736.1 acireductone dioxygenase -
NYP84_RS13430 (NYP84_13430) 2844146..2844835 - 690 WP_259825737.1 acireductone synthase -
NYP84_RS13435 (NYP84_13435) 2844832..2845446 - 615 WP_259817819.1 methylthioribulose 1-phosphate dehydratase -
NYP84_RS13440 (NYP84_13440) 2845893..2846180 - 288 WP_012668982.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYP84_RS13445 (NYP84_13445) 2846185..2846427 - 243 WP_012668983.1 plasmid stabilization protein Antitoxin
NYP84_RS13450 (NYP84_13450) 2846849..2848009 + 1161 WP_259825738.1 pyridoxal phosphate-dependent aminotransferase -
NYP84_RS13455 (NYP84_13455) 2847997..2848770 + 774 WP_259817818.1 amidohydrolase -
NYP84_RS13460 (NYP84_13460) 2848754..2850079 - 1326 WP_259825739.1 nucleobase:cation symporter-2 family protein -
NYP84_RS13465 (NYP84_13465) 2850112..2850447 - 336 WP_259817816.1 hydroxyisourate hydrolase -
NYP84_RS13470 (NYP84_13470) 2850444..2850938 - 495 WP_259825740.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10939.91 Da        Isoelectric Point: 10.7969

>T255051 WP_012668982.1 NZ_CP103445:c2846180-2845893 [Erwinia pyrifoliae]
MIYKVKIRAEALKEWHGLDSAVREQFSKKLKKLRENPHVPSARLTGIAGCYKIKLRSSGFRLVYQVIDEELIIAVVAVGK
RERSQAYKLASERLR

Download         Length: 288 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8820.18 Da        Isoelectric Point: 4.0233

>AT255051 WP_012668983.1 NZ_CP103445:c2846427-2846185 [Erwinia pyrifoliae]
MANLILSDTSASVSELKKNPMATVDAGCGFPVAILNRNQPAFYCIPAPLYERMLEVIDDQELVTLVKARENQPLIDLDLD

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D2T5B9

Antitoxin

Source ID Structure
AlphaFold DB D2T5C0

References