Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2717638..2718266 Replicon chromosome
Accession NZ_CP103445
Organism Erwinia pyrifoliae strain CP201486

Toxin (Protein)


Gene name Hha Uniprot ID D2T444
Locus tag NYP84_RS12800 Protein ID WP_004156337.1
Coordinates 2718048..2718266 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NYP84_RS12795 Protein ID WP_012668861.1
Coordinates 2717638..2718018 (+) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP84_RS12775 (NYP84_12775) 2712969..2716109 + 3141 WP_012668857.1 multidrug efflux RND transporter permease subunit AcrB -
NYP84_RS12780 (NYP84_12780) 2716264..2716524 + 261 WP_012668858.1 type B 50S ribosomal protein L31 -
NYP84_RS12785 (NYP84_12785) 2716535..2716681 + 147 WP_012668859.1 type B 50S ribosomal protein L36 -
NYP84_RS12790 (NYP84_12790) 2717138..2717491 + 354 WP_012668860.1 hypothetical protein -
NYP84_RS12795 (NYP84_12795) 2717638..2718018 + 381 WP_012668861.1 Hha toxicity modulator TomB Antitoxin
NYP84_RS12800 (NYP84_12800) 2718048..2718266 + 219 WP_004156337.1 HHA domain-containing protein Toxin
NYP84_RS12810 (NYP84_12810) 2718565..2718882 + 318 WP_012668862.1 MGMT family protein -
NYP84_RS12815 (NYP84_12815) 2718905..2719462 - 558 WP_012668863.1 YbaY family lipoprotein -
NYP84_RS12820 (NYP84_12820) 2719685..2720545 + 861 WP_012668864.1 acyl-CoA thioesterase II -
NYP84_RS12825 (NYP84_12825) 2720620..2721921 - 1302 WP_012668865.1 ammonium transporter AmtB -
NYP84_RS12830 (NYP84_12830) 2721944..2722282 - 339 WP_012668866.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8627.06 Da        Isoelectric Point: 8.9007

>T255050 WP_004156337.1 NZ_CP103445:2718048-2718266 [Erwinia pyrifoliae]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14721.47 Da        Isoelectric Point: 4.8834

>AT255050 WP_012668861.1 NZ_CP103445:2717638-2718018 [Erwinia pyrifoliae]
MDEYSPKRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSTSNLQLNDLIEHIAAFTMNYKIKHIEDCDLISQIDEYL
DDTFMLFSNYGVNTHDLQRWQKSAKRLFNIFAKECLMSQVQSSHSF

Download         Length: 381 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPQ0

Antitoxin

Source ID Structure

References