Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2278010..2278641 Replicon chromosome
Accession NZ_CP103445
Organism Erwinia pyrifoliae strain CP201486

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NYP84_RS10615 Protein ID WP_259818053.1
Coordinates 2278366..2278641 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NYP84_RS10610 Protein ID WP_259818054.1
Coordinates 2278010..2278369 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP84_RS10585 (NYP84_10585) 2273096..2274823 + 1728 WP_259825666.1 terminase family protein -
NYP84_RS10590 (NYP84_10590) 2274823..2275866 + 1044 WP_259819516.1 phage portal protein -
NYP84_RS10595 (NYP84_10595) 2276311..2276691 - 381 WP_259819514.1 type II toxin-antitoxin system YafO family toxin -
NYP84_RS10600 (NYP84_10600) 2276703..2277296 - 594 WP_259819513.1 hypothetical protein -
NYP84_RS10605 (NYP84_10605) 2277515..2277730 - 216 WP_259818056.1 hypothetical protein -
NYP84_RS10610 (NYP84_10610) 2278010..2278369 - 360 WP_259818054.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NYP84_RS10615 (NYP84_10615) 2278366..2278641 - 276 WP_259818053.1 type II toxin-antitoxin system HicA family toxin Toxin
NYP84_RS10620 (NYP84_10620) 2278712..2281021 - 2310 WP_259825667.1 replication endonuclease -
NYP84_RS10625 (NYP84_10625) 2281237..2282043 - 807 WP_259818050.1 DNA adenine methylase -
NYP84_RS10630 (NYP84_10630) 2282040..2282267 - 228 WP_259819510.1 TraR/DksA family transcriptional regulator -
NYP84_RS10635 (NYP84_10635) 2282267..2282494 - 228 WP_259818047.1 DUF2732 domain-containing protein -
NYP84_RS10640 (NYP84_10640) 2282568..2283119 - 552 WP_259818046.1 hypothetical protein -
NYP84_RS10645 (NYP84_10645) 2283161..2283517 - 357 WP_259818045.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2247065..2288527 41462


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-86)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10127.67 Da        Isoelectric Point: 10.7783

>T255049 WP_259818053.1 NZ_CP103445:c2278641-2278366 [Erwinia pyrifoliae]
MKERVSLLRKKQKSTLEQIFKSPVQSGIRWADVESLIKALGGEVKEGRGSRCKFLLNGSIANFHRPHPSPDTDKGAVANL
RDWLESTGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13209.89 Da        Isoelectric Point: 4.9001

>AT255049 WP_259818054.1 NZ_CP103445:c2278369-2278010 [Erwinia pyrifoliae]
MSKTSTTNTIEIAGQPAVIVFVPELNAFRGKFLGLTGYCDFVSDSIQGLKNEGEISLREYLDDCSAAGIEPYARQEKIKT
FTLRYPESFGERLNQAAAGHETSVNTFIIETLNERMKHA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References