Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2254737..2255347 Replicon chromosome
Accession NZ_CP103445
Organism Erwinia pyrifoliae strain CP201486

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NYP84_RS10455 Protein ID WP_259818088.1
Coordinates 2254737..2255048 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NYP84_RS10460 Protein ID WP_259818087.1
Coordinates 2255051..2255347 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP84_RS10430 (NYP84_10430) 2250949..2251443 - 495 Protein_2015 transposase -
NYP84_RS10435 (NYP84_10435) 2252158..2252410 - 253 Protein_2016 IS110 family transposase -
NYP84_RS10440 (NYP84_10440) 2252514..2253422 - 909 WP_012668491.1 hypothetical protein -
NYP84_RS10445 (NYP84_10445) 2253721..2254037 + 317 Protein_2018 contractile injection system protein, VgrG/Pvc8 family -
NYP84_RS10450 (NYP84_10450) 2254077..2254325 + 249 WP_012668492.1 ogr/Delta-like zinc finger family protein -
NYP84_RS10455 (NYP84_10455) 2254737..2255048 + 312 WP_259818088.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYP84_RS10460 (NYP84_10460) 2255051..2255347 + 297 WP_259818087.1 NadS family protein Antitoxin
NYP84_RS10465 (NYP84_10465) 2255405..2255653 - 249 WP_012668492.1 ogr/Delta-like zinc finger family protein -
NYP84_RS10470 (NYP84_10470) 2255693..2256829 - 1137 WP_259825660.1 phage late control D family protein -
NYP84_RS10475 (NYP84_10475) 2256981..2258162 + 1182 WP_259818085.1 phage tail sheath family protein -
NYP84_RS10480 (NYP84_10480) 2258163..2258678 + 516 WP_259818084.1 phage major tail tube protein -
NYP84_RS10485 (NYP84_10485) 2258726..2259043 + 318 WP_259825661.1 phage tail assembly protein -
NYP84_RS10490 (NYP84_10490) 2259049..2259204 + 156 WP_168400670.1 GpE family phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2247065..2288527 41462


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-87)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12033.69 Da        Isoelectric Point: 7.0154

>T255048 WP_259818088.1 NZ_CP103445:2254737-2255048 [Erwinia pyrifoliae]
MLFIETAIFTEDVKELLTDDEYREFQQFLADNPGWGDVIQQTGGLRKVRWSAKGKGKRGGVRVIYFHKVSESQIRLLLIY
KKGIQDDLSDDEKRQLRTLNEGW

Download         Length: 312 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10915.51 Da        Isoelectric Point: 10.5573

>AT255048 WP_259818087.1 NZ_CP103445:2255051-2255347 [Erwinia pyrifoliae]
MEKKLFERLKESMTQMNEINEGSRDPSRETNVIAVQVKAIRTASGLSQSGFAKLISVNLDTLKNWEQGRREPTGPAKALL
RAIERDPQHVIPALSAKS

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References