254968

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/-
Location 662093..662676 Replicon chromosome
Accession NZ_CP103345
Organism Brucella anthropi strain CGMCC 1.17299

Toxin (Protein)


Gene name hicA Uniprot ID A0A6I0DCD4
Locus tag NW321_RS03090 Protein ID WP_040129739.1
Coordinates 662422..662676 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A1T4LVA5
Locus tag NW321_RS03085 Protein ID WP_012090880.1
Coordinates 662093..662425 (-) Length 111 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW321_RS03045 (NW321_03045) 657562..657708 + 147 WP_158304318.1 hypothetical protein -
NW321_RS03050 (NW321_03050) 657738..657922 + 185 Protein_603 IS5/IS1182 family transposase -
NW321_RS03055 (NW321_03055) 658566..658880 - 315 WP_041545288.1 BrnA antitoxin family protein -
NW321_RS03060 (NW321_03060) 658880..659164 - 285 WP_158304319.1 hypothetical protein -
NW321_RS03065 (NW321_03065) 659343..660524 + 1182 WP_012090877.1 Fic family protein -
NW321_RS03070 (NW321_03070) 660801..660959 + 159 WP_259030353.1 PIN domain-containing protein -
NW321_RS03075 (NW321_03075) 660956..661210 + 255 WP_125301843.1 toxin-antitoxin system HicB family antitoxin -
NW321_RS03080 (NW321_03080) 661512..661938 + 427 Protein_609 type IV secretory system conjugative DNA transfer family protein -
NW321_RS03085 (NW321_03085) 662093..662425 - 333 WP_012090880.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NW321_RS03090 (NW321_03090) 662422..662676 - 255 WP_040129739.1 type II toxin-antitoxin system HicA family toxin Toxin
NW321_RS03095 (NW321_03095) 662690..662965 - 276 WP_235915181.1 hypothetical protein -
NW321_RS03100 (NW321_03100) 663108..664001 + 894 WP_012090883.1 MurR/RpiR family transcriptional regulator -
NW321_RS03105 (NW321_03105) 663982..665853 + 1872 WP_094513471.1 dipeptide ABC transporter ATP-binding protein -
NW321_RS03110 (NW321_03110) 665873..667405 + 1533 WP_040129733.1 glutathione ABC transporter substrate-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 647369..729307 81938


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(23-75)

Antitoxin

(55-105)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 9473.93 Da        Isoelectric Point: 10.5848

>T254968 WP_040129739.1 NZ_CP103345:c662676-662422 [Brucella anthropi]
MKKRHRATLELIFARPVNGSIRWADIEALFVVLGAEVSEREGSRVGVFLFGEVRVFHRPHPSPDTDKGAVASIRKWLDEH
GVKP

Download         Length: 255 bp


Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12050.68 Da        Isoelectric Point: 4.7543

>AT254968 WP_012090880.1 NZ_CP103345:c662425-662093 [Brucella anthropi]
MNNVVEINGEKAVIAFDPEIQMLRGEFVGLNGGADFYAESVHDLIEEGRKSLAVYLEMCREKGIEPRRKFSGKFNVRLTP
DDHAAAVIAAAASGKSLNEWIVGTIREAAE

Download         Length: 333 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A6I0DCD4


Antitoxin

Source ID Structure
AlphaFold DB A0A1T4LVA5

References