Detailed information of TA system TA254733

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2326250..2326829
• Replicon: chromosome
• Accession: NZ_CP102970
• Organism: Staphylococcus aureus strain 09-G-F

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: -
• Locus tag: NW983_RS11580
• Protein ID: WP_258411822.1
• Coordinates: 2326596..2326829 (-)
• Length: 78 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2326250..2326613 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NW983_RS11540 (NW983_11540)	2322105..2324048	-	1944	WP_258411815.1	AAA family ATPase	-
NW983_RS11545 (NW983_11545)	2324057..2324320	-	264	WP_001205732.1	hypothetical protein	-
NW983_RS11550 (NW983_11550)	2324329..2324589	-	261	WP_258411816.1	DUF1108 family protein	-
NW983_RS11555 (NW983_11555)	2324594..2324896	-	303	WP_258411817.1	DUF2482 family protein	-
NW983_RS11560 (NW983_11560)	2324988..2325149	-	162	WP_258411818.1	DUF1270 domain-containing protein	-
NW983_RS11565 (NW983_11565)	2325162..2325425	-	264	WP_258411819.1	helix-turn-helix domain-containing protein	-
NW983_RS11570 (NW983_11570)	2325440..2326195	-	756	WP_258411820.1	phage regulatory protein/antirepressor Ant	-
-	2326250..2326613	+	364	-	-	Antitoxin
NW983_RS11580 (NW983_11580)	2326596..2326829	-	234	WP_258411822.1	DUF2829 domain-containing protein	Toxin
NW983_RS11585 (NW983_11585)	2326872..2327189	-	318	WP_258411823.1	hypothetical protein	-
NW983_RS11590 (NW983_11590)	2327205..2327414	-	210	WP_047447803.1	helix-turn-helix transcriptional regulator	-
NW983_RS11595 (NW983_11595)	2327611..2328240	+	630	WP_258411824.1	XRE family transcriptional regulator	-
NW983_RS11600 (NW983_11600)	2328255..2329145	+	891	WP_258411825.1	exonuclease domain-containing protein	-
NW983_RS11605 (NW983_11605)	2329285..2329908	-	624	WP_258411826.1	hypothetical protein	-
NW983_RS11610 (NW983_11610)	2330034..2331239	+	1206	WP_258411827.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2286894..2341065	54171

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8909.10 Da
• Isoelectric Point: 5.7783

>T254733 WP_258411822.1 NZ_CP102970:c2326829-2326596 [Staphylococcus aureus]
MNIQEATKLATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISSSDGKSLVRYWQPSADDLMANDWEVVNPIRDQEL

Nucleotide

• Length: 234 bp

Antitoxin

Nucleotide

• Length: 364 bp

>AT254733 NZ_CP102970:2326250-2326613 [Staphylococcus aureus]
ATGCCCTTGATATCCGATGAATTTGAGACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAATCAGGTTCTGTTAAATTAAGTTGTAATAATTTCGATGATGCTGAAGGTATACATTTAAAGTATTTTC
AAAAGTTGCATTTCGAAGATGTCGACAATGATTTAAAAAAACTTAAAAACTCCGGATTCCTCCATGGTGTGATTGCAGAC
AACACTATTTATCATGTGACAATATCGGATAAGACTATTGTTTATTTCGAAAATAAGTTTAAAAACAATTTAAAAAGTAT
AATTGATAGTATTTCTAGTATTGCTTCTATAATTCCTGGTCTCT

Structures

Antitoxin