Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2391547..2392076 Replicon chromosome
Accession NC_015758
Organism Mycobacterium africanum GM041182

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag MAF_RS11165 Protein ID WP_003411124.1
Coordinates 2391547..2391864 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag MAF_RS11170 Protein ID WP_003411127.1
Coordinates 2391861..2392076 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAF_RS11135 2386568..2387644 + 1077 WP_003411110.1 hypothetical protein -
MAF_RS11140 2387641..2387922 + 282 WP_003411112.1 hypothetical protein -
MAF_RS11145 2387958..2389031 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
MAF_RS11150 2389036..2389566 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
MAF_RS11155 2389614..2390960 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
MAF_RS11165 2391547..2391864 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MAF_RS11170 2391861..2392076 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
MAF_RS11175 2392331..2393389 + 1059 WP_003411129.1 hypothetical protein -
MAF_RS11180 2393519..2393875 - 357 WP_003411130.1 hypothetical protein -
MAF_RS11185 2393970..2394752 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
MAF_RS11190 2395020..2395310 - 291 WP_003900476.1 YggT family protein -
MAF_RS11195 2395472..2396128 - 657 WP_003411133.1 cell division protein SepF -
MAF_RS11200 2396194..2396970 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T25471 WP_003411124.1 NC_015758:c2391864-2391547 [Mycobacterium tuberculosis variant africanum GM041182]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T25471 NC_015758:c2391864-2391547 [Mycobacterium tuberculosis variant africanum GM041182]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT25471 WP_003411127.1 NC_015758:c2392076-2391861 [Mycobacterium tuberculosis variant africanum GM041182]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT25471 NC_015758:c2392076-2391861 [Mycobacterium tuberculosis variant africanum GM041182]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References