Detailed information of TA system TA254689

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1106400..1106979
• Replicon: chromosome
• Accession: NZ_CP102963
• Organism: Staphylococcus aureus strain 40-B-50

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: -
• Locus tag: NW941_RS05285
• Protein ID: WP_258411822.1
• Coordinates: 1106400..1106633 (+)
• Length: 78 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1106616..1106979 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NW941_RS05245 (NW941_05270)	1102015..1103046	-	1032	WP_258412913.1	site-specific integrase	-
NW941_RS05250 (NW941_05275)	1103153..1103497	-	345	WP_258412914.1	DUF3969 family protein	-
NW941_RS05255 (NW941_05280)	1103497..1103979	-	483	WP_258412915.1	hypothetical protein	-
NW941_RS05260 (NW941_05285)	1104148..1104762	-	615	WP_258415209.1	hypothetical protein	-
NW941_RS05265 (NW941_05290)	1104787..1105248	-	462	WP_258412917.1	toxin	-
NW941_RS05270 (NW941_05295)	1105261..1105593	-	333	WP_258412918.1	helix-turn-helix transcriptional regulator	-
NW941_RS05275 (NW941_05300)	1105757..1105966	+	210	WP_196429541.1	helix-turn-helix transcriptional regulator	-
NW941_RS05280 (NW941_05305)	1106040..1106357	+	318	WP_196429542.1	hypothetical protein	-
NW941_RS05285 (NW941_05310)	1106400..1106633	+	234	WP_258411822.1	DUF2829 domain-containing protein	Toxin
-	1106616..1106979	-	364	-	-	Antitoxin
NW941_RS05295 (NW941_05320)	1107034..1107717	+	684	WP_258412920.1	BRO family protein	-
NW941_RS05300 (NW941_05325)	1107733..1107948	+	216	WP_258412921.1	DUF771 domain-containing protein	-
NW941_RS05305 (NW941_05330)	1107963..1108124	+	162	WP_209025520.1	DUF1270 family protein	-
NW941_RS05310 (NW941_05335)	1108219..1108521	+	303	WP_258411295.1	DUF2482 family protein	-
NW941_RS05315 (NW941_05340)	1108526..1108786	+	261	WP_113555199.1	DUF1108 family protein	-
NW941_RS05320 (NW941_05345)	1108795..1109058	+	264	WP_001205732.1	hypothetical protein	-
NW941_RS05325 (NW941_05350)	1109067..1111011	+	1945	Protein_1038	AAA family ATPase	-
NW941_RS05330 (NW941_05355)	1111013..1111933	+	921	WP_258415210.1	recombinase RecT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hly/hla	1087773..1142697	54924

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8909.10 Da
• Isoelectric Point: 5.7783

>T254689 WP_258411822.1 NZ_CP102963:1106400-1106633 [Staphylococcus aureus]
MNIQEATKLATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISSSDGKSLVRYWQPSADDLMANDWEVVNPIRDQEL

Nucleotide

• Length: 234 bp

Antitoxin

Nucleotide

• Length: 364 bp

>AT254689 NZ_CP102963:c1106979-1106616 [Staphylococcus aureus]
ATGCCCTTGATATCCGATGAATTTGAGACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAATCAGGTTCTGTTAAATTAAGTTGTAATAATTTCGATGATGCTGAAGGTATACATTTAAAGTATTTTC
AAAAGTTGCATTTCGAAGATGTCGACAATGATTTAAAAAAACTTAAAAACTCCGGATTCCTCCATGGTGTGCTTGCAGAC
AACACTATTTATCATGTGACAATATCGGATAAGACTATTGTTTATTTCGAAAATAAGTTTAAAAACAATTTAAAAAGTAT
AATTGATAGTATTTCTAGTATTGCTTCTATAATTCCTGGTCTCT

Structures

Antitoxin