Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2438771..2438955 Replicon chromosome
Accession NZ_CP102952
Organism Staphylococcus aureus strain 39-B-49

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag NW967_RS12010 Protein ID WP_000482650.1
Coordinates 2438848..2438955 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2438771..2438831 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW967_RS11995 (NW967_11995) 2434225..2434392 - 168 WP_001790576.1 hypothetical protein -
NW967_RS12000 (NW967_12000) 2434623..2436356 - 1734 WP_258411336.1 ABC transporter ATP-binding protein -
NW967_RS12005 (NW967_12005) 2436381..2438144 - 1764 WP_258411337.1 ABC transporter ATP-binding protein -
- 2438771..2438831 + 61 - - Antitoxin
NW967_RS12010 (NW967_12010) 2438848..2438955 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
NW967_RS12015 (NW967_12015) 2439089..2439475 - 387 WP_000779360.1 flippase GtxA -
NW967_RS12020 (NW967_12020) 2439733..2440875 + 1143 WP_258411344.1 glycerate kinase -
NW967_RS12025 (NW967_12025) 2440935..2441594 + 660 WP_000831298.1 membrane protein -
NW967_RS12030 (NW967_12030) 2441776..2442987 + 1212 WP_258411345.1 multidrug effflux MFS transporter -
NW967_RS12035 (NW967_12035) 2443110..2443583 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T254593 WP_000482650.1 NZ_CP102952:c2438955-2438848 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT254593 NZ_CP102952:2438771-2438831 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References