Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1971902..1973538 Replicon chromosome
Accession NZ_CP102934
Organism Acinetobacter sp. AOR07_HL

Toxin (Protein)


Gene name hipA Uniprot ID A0A9F1U5K1
Locus tag MKL45_RS09460 Protein ID WP_005128640.1
Coordinates 1972207..1973538 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MKL45_RS09455 Protein ID WP_001101310.1
Coordinates 1971902..1972210 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKL45_RS09430 (MKL45_09435) 1967265..1967978 + 714 WP_005128644.1 hypothetical protein -
MKL45_RS09435 (MKL45_09440) 1967991..1969100 + 1110 WP_005128643.1 XRE family transcriptional regulator -
MKL45_RS09440 (MKL45_09445) 1969163..1969711 - 549 WP_005128641.1 TetR/AcrR family transcriptional regulator -
MKL45_RS09445 (MKL45_09450) 1970134..1970643 + 510 WP_230258700.1 helix-turn-helix domain-containing protein -
MKL45_RS09450 (MKL45_09455) 1970676..1971518 + 843 WP_223673390.1 IS3 family transposase -
MKL45_RS09455 (MKL45_09460) 1971902..1972210 - 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
MKL45_RS09460 (MKL45_09465) 1972207..1973538 - 1332 WP_005128640.1 HipA domain-containing protein Toxin
MKL45_RS09465 (MKL45_09470) 1973834..1974274 + 441 WP_000193136.1 HD domain-containing protein -
MKL45_RS09470 (MKL45_09475) 1974309..1974953 - 645 WP_005128638.1 hypothetical protein -
MKL45_RS09475 (MKL45_09480) 1974965..1975936 - 972 WP_086267245.1 5'/3'-nucleotidase SurE -
MKL45_RS09480 (MKL45_09485) 1976063..1977241 - 1179 WP_227504097.1 TolC family protein -
MKL45_RS09485 (MKL45_09490) 1977245..1977811 - 567 Protein_1851 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51189.25 Da        Isoelectric Point: 4.8549

>T254501 WP_005128640.1 NZ_CP102934:c1973538-1972207 [Acinetobacter sp. AOR07_HL]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT254501 WP_001101310.1 NZ_CP102934:c1972210-1971902 [Acinetobacter sp. AOR07_HL]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References