Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 838363..839072 Replicon chromosome
Accession NC_015758
Organism Mycobacterium africanum GM041182

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag MAF_RS03940 Protein ID WP_003403837.1
Coordinates 838644..839072 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A109SUH0
Locus tag MAF_RS03935 Protein ID WP_003910195.1
Coordinates 838363..838620 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAF_RS03930 836020..838272 + 2253 WP_013988768.1 PE family protein -
MAF_RS03935 838363..838620 + 258 WP_003910195.1 ribbon-helix-helix protein, CopG family Antitoxin
MAF_RS03940 838644..839072 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
MAF_RS03945 839162..839336 - 175 Protein_780 transposase -
MAF_RS03950 839449..839694 + 246 WP_003403841.1 hypothetical protein -
MAF_RS03955 839763..840647 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
MAF_RS03960 840658..841830 - 1173 WP_003910196.1 acyl-CoA dehydrogenase FadE9 -
MAF_RS03965 841837..843369 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T25448 WP_003403837.1 NC_015758:838644-839072 [Mycobacterium tuberculosis variant africanum GM041182]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T25448 NC_015758:838644-839072 [Mycobacterium tuberculosis variant africanum GM041182]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CTGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9072.20 Da        Isoelectric Point: 10.6530

>AT25448 WP_003910195.1 NC_015758:838363-838620 [Mycobacterium tuberculosis variant africanum GM041182]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTGPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT25448 NC_015758:838363-838620 [Mycobacterium tuberculosis variant africanum GM041182]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGGCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB A0A109SUH0

References