Detailed information of TA system TA254233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5029232..5030913
• Replicon: chromosome
• Accession: NZ_CP102833
• Organism: Klebsiella pneumoniae strain KP4962

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: NV394_RS24655
• Protein ID: WP_004146663.1
• Coordinates: 5029232..5030149 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: NV394_RS24660
• Protein ID: WP_004177809.1
• Coordinates: 5030155..5030913 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NV394_RS24635 (5024538)	5024538..5026058	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
NV394_RS24640 (5026055)	5026055..5027053	+	999	WP_002885172.1	ribose ABC transporter permease	-
NV394_RS24645 (5027084)	5027084..5028025	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
NV394_RS24650 (5028100)	5028100..5029107	+	1008	WP_004221949.1	carbohydrate kinase family protein	-
NV394_RS24655 (5029232)	5029232..5030149	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NV394_RS24660 (5030155)	5030155..5030913	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
NV394_RS24665 (5030999)	5030999..5031727	-	729	WP_004177810.1	response regulator transcription factor	-
NV394_RS24670 (5032000)	5032000..5034147	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
NV394_RS24675 (5034609)	5034609..5035295	+	687	WP_032421940.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T254233 WP_004146663.1 NZ_CP102833:c5030149-5029232 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT254233 WP_004177809.1 NZ_CP102833:c5030913-5030155 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05