Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 859367..859859 Replicon chromosome
Accession NZ_CP102746
Organism Streptococcus suis strain Transconjugant cAKJ47-2

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag NWE23_RS04195 Protein ID WP_011922404.1
Coordinates 859367..859624 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag NWE23_RS04200 Protein ID WP_012775104.1
Coordinates 859608..859859 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWE23_RS04175 (NWE23_04185) 855001..856071 + 1071 WP_012775436.1 tyrosine recombinase XerS -
NWE23_RS04180 (NWE23_04190) 856141..857649 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
NWE23_RS04185 (NWE23_04195) 857725..858666 - 942 WP_012775102.1 sensor histidine kinase -
NWE23_RS04190 (NWE23_04200) 858663..859328 - 666 WP_012775103.1 response regulator transcription factor -
NWE23_RS04195 (NWE23_04205) 859367..859624 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NWE23_RS04200 (NWE23_04210) 859608..859859 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
NWE23_RS04205 (NWE23_04215) 859951..861921 - 1971 WP_012775105.1 FtsX-like permease family protein -
NWE23_RS04210 (NWE23_04220) 861922..862674 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
NWE23_RS04215 (NWE23_04225) 862810..863544 - 735 WP_011922410.1 ABC transporter permease -
NWE23_RS04220 (NWE23_04230) 863546..864292 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T254109 WP_011922404.1 NZ_CP102746:c859624-859367 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT254109 WP_012775104.1 NZ_CP102746:c859859-859608 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References