Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 666072..666733 Replicon chromosome
Accession NC_015690
Organism Paenibacillus mucilaginosus KNP414

Toxin (Protein)


Gene name pemK Uniprot ID A0A916K9N6
Locus tag KNP414_RS03000 Protein ID WP_014649298.1
Coordinates 666383..666733 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KNP414_RS02995 Protein ID WP_013914410.1
Coordinates 666072..666377 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KNP414_RS02975 661473..662879 + 1407 WP_013914408.1 undecaprenyl-phosphate glucose phosphotransferase -
KNP414_RS35940 663109..664469 + 1361 Protein_539 outer membrane lipoprotein carrier protein LolA -
KNP414_RS02990 664668..665852 + 1185 WP_013914409.1 alanine racemase -
KNP414_RS02995 666072..666377 + 306 WP_013914410.1 CopG family ribbon-helix-helix protein Antitoxin
KNP414_RS03000 666383..666733 + 351 WP_014649298.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KNP414_RS03005 666864..669044 + 2181 WP_187296759.1 RNA-binding transcriptional accessory protein -
KNP414_RS36995 669214..669366 - 153 WP_143768091.1 cortex morphogenetic protein CmpA -
KNP414_RS03010 669464..669832 - 369 WP_013914414.1 hypothetical protein -
KNP414_RS03015 669988..670464 + 477 WP_013914415.1 SprT family protein -
KNP414_RS03035 671191..671610 + 420 WP_013914416.1 pyridoxamine 5'-phosphate oxidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(17-54)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12890.84 Da        Isoelectric Point: 4.8837

>T25409 WP_014649298.1 NC_015690:666383-666733 [Paenibacillus mucilaginosus KNP414]
MIVKRGDVFFADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAEAHGFDRDSVILLEQI
RTIDKQRLTDKITHLDEETMRKVDDALQISVGLIEF

Download         Length: 351 bp

>T25409 NC_015690:666383-666733 [Paenibacillus mucilaginosus KNP414]
TTGATTGTCAAACGTGGCGATGTCTTTTTCGCAGATCTGTCCCCCGTGGTGGGGTCCGAGCAGGGCGGTATCCGGCCCGT
TCTGATCATTCAGAATGATATCGGTAACAGATTCAGTCCCACGGTCATCGTGGCGGCCATTACGGCCCAGATTCAGAAAG
CCAAGCTGCCCACGCATGTGGAGATCGACGCGGAAGCGCACGGTTTTGACAGGGATTCCGTCATCCTTCTGGAGCAGATC
CGCACCATAGACAAACAGCGTCTTACAGATAAGATTACCCATCTGGATGAAGAAACCATGCGCAAGGTCGATGACGCCCT
TCAGATAAGTGTCGGACTGATTGAATTTTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11867.61 Da        Isoelectric Point: 6.4868

>AT25409 WP_013914410.1 NC_015690:666072-666377 [Paenibacillus mucilaginosus KNP414]
MFLGVHDQVANVQNTKRIMISLPDHLLQEVDYLVEKENSNRSEFIRQAMKLYLTERKKRHLRETMQRGYMEMAKINLHMA
SEAFQAEEEADTTLDRLVSGV

Download         Length: 306 bp

>AT25409 NC_015690:666072-666377 [Paenibacillus mucilaginosus KNP414]
ATGTTTTTGGGGGTGCATGATCAGGTGGCCAATGTGCAGAACACGAAACGAATTATGATCAGTTTACCGGACCATTTGCT
GCAGGAGGTGGACTATCTCGTGGAAAAGGAAAATTCCAATCGGAGCGAGTTCATCCGACAAGCGATGAAGCTTTATTTGA
CTGAGCGCAAGAAGCGGCATTTGCGTGAAACCATGCAGCGTGGATACATGGAAATGGCCAAGATCAACCTTCATATGGCC
TCGGAAGCATTCCAAGCGGAGGAAGAGGCGGATACAACGCTTGACCGTCTGGTGAGCGGGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References