Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4113413..4114073 Replicon chromosome
Accession NZ_CP102719
Organism Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS1

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NWA05_RS20120 Protein ID WP_000244756.1
Coordinates 4113413..4113826 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NWA05_RS20125 Protein ID WP_000351186.1
Coordinates 4113807..4114073 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NWA05_RS20100 (4109354) 4109354..4111087 - 1734 WP_023223830.1 single-stranded-DNA-specific exonuclease RecJ -
NWA05_RS20105 (4111093) 4111093..4111806 - 714 WP_023223829.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NWA05_RS20110 (4111830) 4111830..4112726 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NWA05_RS20115 (4112839) 4112839..4113360 + 522 WP_001055885.1 flavodoxin FldB -
NWA05_RS20120 (4113413) 4113413..4113826 - 414 WP_000244756.1 protein YgfX Toxin
NWA05_RS20125 (4113807) 4113807..4114073 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NWA05_RS20130 (4114323) 4114323..4115303 + 981 WP_000874178.1 tRNA-modifying protein YgfZ -
NWA05_RS20135 (4115419) 4115419..4116078 - 660 WP_000250289.1 hemolysin III family protein -
NWA05_RS20140 (4116242) 4116242..4116553 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NWA05_RS20145 (4116711) 4116711..4118144 + 1434 WP_001230143.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T254082 WP_000244756.1 NZ_CP102719:c4113826-4113413 [Salmonella enterica subsp. enterica serovar Kentucky]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT254082 WP_000351186.1 NZ_CP102719:c4114073-4113807 [Salmonella enterica subsp. enterica serovar Kentucky]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References