Detailed information of TA system TA254073

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1307212..1307626
• Replicon: chromosome
• Accession: NZ_CP102719
• Organism: Salmonella enterica subsp. enterica serovar Kentucky isolate AH19MCS1

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: NWA05_RS06270
• Protein ID: WP_023203422.1
• Coordinates: 1307212..1307469 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1307294..1307626 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NWA05_RS06255	1305537..1306058	+	522	WP_023203424.1	SMI1/KNR4 family protein	-
NWA05_RS06260	1306419..1306826	+	408	WP_024146273.1	DUF4329 domain-containing protein	-
NWA05_RS06265	1306845..1307153	+	309	WP_023203423.1	hypothetical protein	-
NWA05_RS06270	1307212..1307469	-	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
-	1307294..1307626	+	333	-	-	Antitoxin
NWA05_RS06275	1308542..1308817	+	276	WP_223163371.1	hypothetical protein	-
NWA05_RS06280	1308910..1309377	+	468	WP_000828182.1	sugar tyrosine-protein kinase	-
NWA05_RS06285	1309695..1309973	+	279	WP_012664366.1	hypothetical protein	-
NWA05_RS06290	1310118..1310354	-	237	Protein_1214	type I toxin-antitoxin system SymE family toxin	-
NWA05_RS06295	1310407..1311111	+	705	Protein_1215	integrase core domain-containing protein	-
NWA05_RS06300	1311872..1312369	+	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1275124..1328456	53332
	-	flank	IS/Tn	-	-	1310830..1311111	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T254073 WP_023203422.1 NZ_CP102719:c1307469-1307212 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

Antitoxin

Nucleotide

• Length: 333 bp

>AT254073 NZ_CP102719:1307294-1307626 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin