Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4873911..4875592 Replicon chromosome
Accession NZ_CP102692
Organism Klebsiella pneumoniae strain GN4542

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NV951_RS23860 Protein ID WP_002885155.1
Coordinates 4873911..4874828 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A2L1C4M5
Locus tag NV951_RS23865 Protein ID WP_004192584.1
Coordinates 4874834..4875592 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NV951_RS23840 (NV951_23835) 4869217..4870737 + 1521 WP_004177791.1 sugar ABC transporter ATP-binding protein -
NV951_RS23845 (NV951_23840) 4870734..4871732 + 999 WP_002885172.1 ribose ABC transporter permease -
NV951_RS23850 (NV951_23845) 4871763..4872704 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NV951_RS23855 (NV951_23850) 4872779..4873786 + 1008 WP_049109012.1 carbohydrate kinase family protein -
NV951_RS23860 (NV951_23855) 4873911..4874828 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NV951_RS23865 (NV951_23860) 4874834..4875592 - 759 WP_004192584.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NV951_RS23870 (NV951_23865) 4875678..4876406 - 729 WP_002885152.1 response regulator transcription factor -
NV951_RS23875 (NV951_23870) 4876679..4878826 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
NV951_RS23880 (NV951_23875) 4879056..4879742 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T254027 WP_002885155.1 NZ_CP102692:c4874828-4873911 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28582.94 Da        Isoelectric Point: 10.0870

>AT254027 WP_004192584.1 NZ_CP102692:c4875592-4874834 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1C4M5

References