Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2186384..2186979 Replicon chromosome
Accession NZ_CP102675
Organism Escherichia coli strain XH987

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NU950_RS12615 Protein ID WP_000239579.1
Coordinates 2186384..2186734 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NU950_RS12620 Protein ID WP_001223208.1
Coordinates 2186728..2186979 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU950_RS12595 (2181660) 2181660..2182682 - 1023 WP_001296689.1 ABC transporter permease -
NU950_RS12600 (2182696) 2182696..2184198 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
NU950_RS12605 (2184508) 2184508..2185464 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NU950_RS12610 (2185774) 2185774..2186304 + 531 WP_000055072.1 inorganic diphosphatase -
NU950_RS12615 (2186384) 2186384..2186734 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NU950_RS12620 (2186728) 2186728..2186979 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NU950_RS12625 (2187192) 2187192..2187533 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NU950_RS12630 (2187536) 2187536..2191315 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T253945 WP_000239579.1 NZ_CP102675:c2186734-2186384 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT253945 WP_001223208.1 NZ_CP102675:c2186979-2186728 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References