253776

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 72662..73184 Replicon plasmid pIncFIBK
Accession NZ_CP102492
Organism Klebsiella pneumoniae strain BA13643

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag LCN95_RS27030 Protein ID WP_004187019.1
Coordinates 72900..73184 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag LCN95_RS27025 Protein ID WP_004187025.1
Coordinates 72662..72910 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCN95_RS26995 (LCN95_27000) 70029..70598 - 570 WP_267272358.1 small heat shock protein sHSP20 -
LCN95_RS27000 (LCN95_27005) 70633..70914 - 282 WP_013307885.1 helix-turn-helix domain-containing protein -
LCN95_RS27005 (LCN95_27010) 71158..71421 - 264 WP_004118208.1 hypothetical protein -
LCN95_RS27010 (LCN95_27015) 71436..71699 + 264 WP_004187027.1 transposase -
LCN95_RS27015 (LCN95_27020) 71644..71760 + 117 Protein_75 transposase domain-containing protein -
LCN95_RS27020 (LCN95_27025) 71948..72372 + 425 Protein_76 IS1 family transposase -
LCN95_RS27025 (LCN95_27030) 72662..72910 + 249 WP_004187025.1 plasmid stabilization protein Antitoxin
LCN95_RS27030 (LCN95_27035) 72900..73184 + 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCN95_RS27035 (LCN95_27040) 73200..74555 - 1356 WP_004187017.1 ISNCY family transposase -
LCN95_RS27040 (LCN95_27045) 74637..74888 - 252 Protein_80 conjugal transfer protein TraH -
LCN95_RS27045 (LCN95_27050) 75545..75958 - 414 WP_267272359.1 hypothetical protein -
LCN95_RS27050 (LCN95_27055) 77501..77965 + 465 WP_004187010.1 conjugative transfer protein MobI(A/C) -
LCN95_RS27055 (LCN95_27060) 77965..78165 + 201 WP_227525533.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkA / mrkB / mrkC / mrkF / mrkJ 1..112905 112905
- flank IS/Tn - - 72142..72408 266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T253776 WP_004187019.1 NZ_CP102492:72900-73184 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT253776 WP_004187025.1 NZ_CP102492:72662-72910 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References