Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2579956..2580695 Replicon chromosome
Accession NZ_CP102479
Organism Klebsiella aerogenes strain TS2020

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag NUT96_RS12320 Protein ID WP_032705770.1
Coordinates 2580210..2580695 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag NUT96_RS12315 Protein ID WP_015705366.1
Coordinates 2579956..2580222 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUT96_RS12290 (2575291) 2575291..2575878 + 588 WP_015705371.1 hypothetical protein -
NUT96_RS12295 (2575875) 2575875..2577194 + 1320 WP_015705370.1 ATP-binding protein -
NUT96_RS12300 (2577194) 2577194..2577811 + 618 WP_015705369.1 response regulator -
NUT96_RS12305 (2577907) 2577907..2578404 + 498 WP_032708018.1 heme-binding protein -
NUT96_RS12310 (2578448) 2578448..2579683 - 1236 WP_020078885.1 MFS transporter -
NUT96_RS12315 (2579956) 2579956..2580222 + 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
NUT96_RS12320 (2580210) 2580210..2580695 + 486 WP_032705770.1 GNAT family N-acetyltransferase Toxin
NUT96_RS12325 (2580767) 2580767..2582383 + 1617 WP_032708017.1 FAD-NAD(P)-binding protein -
NUT96_RS12330 (2582502) 2582502..2583602 + 1101 WP_032708016.1 NADH:flavin oxidoreductase/NADH oxidase -
NUT96_RS12335 (2583659) 2583659..2583817 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
NUT96_RS12340 (2584078) 2584078..2585148 + 1071 WP_075648509.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17573.23 Da        Isoelectric Point: 8.8793

>T253716 WP_032705770.1 NZ_CP102479:2580210-2580695 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHSEATGGLRRNM
PDPIPVIILARLAIDCAFHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT253716 WP_015705366.1 NZ_CP102479:2579956-2580222 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References