Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3035154..3035793 Replicon chromosome
Accession NZ_CP102463
Organism Burkholderia contaminans strain NML151013

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NUJ29_RS31760 Protein ID WP_226285408.1
Coordinates 3035154..3035570 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1PQC0
Locus tag NUJ29_RS31765 Protein ID WP_039351245.1
Coordinates 3035557..3035793 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ29_RS31735 (NUJ29_31735) 3030321..3031409 - 1089 WP_105816535.1 nitronate monooxygenase -
NUJ29_RS31740 (NUJ29_31740) 3031406..3032338 - 933 WP_071332494.1 enoyl-CoA hydratase -
NUJ29_RS31745 (NUJ29_31745) 3032347..3033144 - 798 WP_105816536.1 ketoacid CoA transferase -
NUJ29_RS31750 (NUJ29_31750) 3033155..3034048 - 894 WP_046547957.1 CoA-transferase -
NUJ29_RS31755 (NUJ29_31755) 3034058..3034954 - 897 WP_039350875.1 VOC family protein -
NUJ29_RS31760 (NUJ29_31760) 3035154..3035570 - 417 WP_226285408.1 type II toxin-antitoxin system VapC family toxin Toxin
NUJ29_RS31765 (NUJ29_31765) 3035557..3035793 - 237 WP_039351245.1 DNA-binding protein Antitoxin
NUJ29_RS31770 (NUJ29_31770) 3036191..3036577 - 387 Protein_2724 hypothetical protein -
NUJ29_RS31775 (NUJ29_31775) 3036738..3037973 + 1236 WP_105816538.1 acyltransferase -
NUJ29_RS31780 (NUJ29_31780) 3038050..3038823 - 774 WP_105816539.1 SDR family oxidoreductase -
NUJ29_RS31785 (NUJ29_31785) 3038862..3040442 - 1581 WP_105816540.1 FadD3 family acyl-CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15312.64 Da        Isoelectric Point: 8.5735

>T253693 WP_226285408.1 NZ_CP102463:c3035570-3035154 [Burkholderia contaminans]
VYLIDTNIISEIRKGKRTNRGVRAFFRQAAADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWMATILSGYAPNI
LPVDIEISQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVADFARTGVKLLNPFD

Download         Length: 417 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8598.61 Da        Isoelectric Point: 5.0477

>AT253693 WP_039351245.1 NZ_CP102463:c3035793-3035557 [Burkholderia contaminans]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILADALGRPKRKTFAQVLMSMPDVGDDADFQRVQDSGEARRVFD

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1PQC0

References