Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 305940..306595 Replicon chromosome
Accession NZ_CP102463
Organism Burkholderia contaminans strain NML151013

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NUJ29_RS19450 Protein ID WP_105818098.1
Coordinates 305940..306359 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NUJ29_RS19455 Protein ID WP_105818099.1
Coordinates 306356..306595 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ29_RS19425 (NUJ29_19425) 301341..302135 + 795 WP_105818096.1 AraC family transcriptional regulator -
NUJ29_RS19430 (NUJ29_19430) 302335..303303 + 969 WP_224756093.1 DMT family transporter -
NUJ29_RS19435 (NUJ29_19435) 303512..304060 + 549 WP_105818378.1 permease -
NUJ29_RS19440 (NUJ29_19440) 304159..304293 - 135 WP_006485835.1 entericidin A/B family lipoprotein -
NUJ29_RS19445 (NUJ29_19445) 304527..305822 + 1296 WP_039360985.1 aspartate carbamoyltransferase -
NUJ29_RS19450 (NUJ29_19450) 305940..306359 - 420 WP_105818098.1 type II toxin-antitoxin system VapC family toxin Toxin
NUJ29_RS19455 (NUJ29_19455) 306356..306595 - 240 WP_105818099.1 Arc family DNA-binding protein Antitoxin
NUJ29_RS19460 (NUJ29_19460) 306907..309150 + 2244 WP_105818100.1 TonB-dependent siderophore receptor -
NUJ29_RS19465 (NUJ29_19465) 309154..309900 + 747 WP_105818101.1 tetratricopeptide repeat protein -
NUJ29_RS19470 (NUJ29_19470) 309930..310613 + 684 WP_105818102.1 Fe2+-dependent dioxygenase -
NUJ29_RS19475 (NUJ29_19475) 310710..310949 + 240 WP_011659184.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
NUJ29_RS19480 (NUJ29_19480) 310946..311341 + 396 WP_039361042.1 type II toxin-antitoxin system VapC family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15079.31 Da        Isoelectric Point: 5.7471

>T253690 WP_105818098.1 NZ_CP102463:c306359-305940 [Burkholderia contaminans]
MILVDTNVMSEPLRREPSTAVIEWLDAQNVETLFLAAISLGEMRFGVAALPEGRRRDWLHHGIEQRVVPLFRGRILPFDD
AASKAYASIRARARASGSAIAPADVFIAATAEANGLIIATRDGAPFEAVGLRVIDPWAS

Download         Length: 420 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8762.03 Da        Isoelectric Point: 6.4684

>AT253690 WP_105818099.1 NZ_CP102463:c306595-306356 [Burkholderia contaminans]
MPVITVRNLPDEVHRALRVRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTLLAEIGREAGGVEFDVRRDKTLTDPMSFE

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References