Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | rnlAB/RnlA-RnlB |
| Location | 2776554..2777991 | Replicon | chromosome |
| Accession | NZ_CP102378 | ||
| Organism | Escherichia coli strain JB41 | ||
Toxin (Protein)
| Gene name | rnlA | Uniprot ID | P52129 |
| Locus tag | NR351_RS13630 | Protein ID | WP_000155570.1 |
| Coordinates | 2776554..2777627 (+) | Length | 358 a.a. |
Antitoxin (Protein)
| Gene name | rnlB | Uniprot ID | P52130 |
| Locus tag | NR351_RS13635 | Protein ID | WP_000461704.1 |
| Coordinates | 2777620..2777991 (+) | Length | 124 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NR351_RS13615 (2771987) | 2771987..2774176 | - | 2190 | WP_000136402.1 | DEAD/DEAH box helicase | - |
| NR351_RS13620 (2774173) | 2774173..2775789 | - | 1617 | WP_000445380.1 | anti-bacteriophage protein AbpA | - |
| NR351_RS13625 (2776149) | 2776149..2776412 | - | 264 | WP_000502050.1 | DUF1524 domain-containing protein | - |
| NR351_RS13630 (2776554) | 2776554..2777627 | + | 1074 | WP_000155570.1 | type II toxin-antitoxin system toxin mRNA endoribonuclease RnlA | Toxin |
| NR351_RS13635 (2777620) | 2777620..2777991 | + | 372 | WP_000461704.1 | type II toxin-antitoxin system antitoxin RnlB | Antitoxin |
| NR351_RS13640 (2778346) | 2778346..2779209 | + | 864 | WP_000787597.1 | GTPase family protein | - |
| NR351_RS13645 (2779301) | 2779301..2780122 | + | 822 | WP_000197391.1 | DUF932 domain-containing protein | - |
| NR351_RS13650 (2780339) | 2780339..2781040 | + | 702 | WP_000189409.1 | WYL domain-containing protein | - |
| NR351_RS13655 (2781081) | 2781081..2781317 | + | 237 | WP_001144029.1 | protein YpjK | - |
| NR351_RS13660 (2781317) | 2781317..2781760 | + | 444 | WP_000824222.1 | lipoprotein YfjS | - |
| NR351_RS13665 (2781784) | 2781784..2782251 | + | 468 | WP_000702495.1 | protein YfjT | - |
| NR351_RS13670 (2782638) | 2782638..2782790 | - | 153 | Protein_2672 | arsenate reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 358 a.a. Molecular weight: 40061.13 Da Isoelectric Point: 6.8293
>T253513 WP_000155570.1 NZ_CP102378:2776554-2777627 [Escherichia coli]
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
MTIRSYKNLNLVRANIETESRQFIENKNYSIQSIGPMPGSRAGLRVVFTRPGVNLATVDIFYNGDGSTTIQYLTGANRSL
GQELADHLFETINPAEFEQVNMVLQGFVETSVLPVLELSADESHIEFREHSRNAHTVVWKIISTSYQDELTVSLHITTGK
LQIQGRPLSCYRVFTFNLAALLDLQGLEKVLIRQEDGKANIVQQEVARTYLQTVMADAYPHLHVTAEKLLVSGLCVKLAA
PDLPDYCMLLYPELRTIEGVLKSKMSGLGMPVQQPAGFGTYFDKPAAHYILKPQFAATLRPEQINIISTAYTFFNVERHS
LFHMETVVDASRMISDMARLMGKATRAWGIIKDLYIV
Download Length: 1074 bp
Antitoxin
Download Length: 124 a.a. Molecular weight: 13664.69 Da Isoelectric Point: 4.2391
>AT253513 WP_000461704.1 NZ_CP102378:2777620-2777991 [Escherichia coli]
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
MFEITGINVSGALKAVVMATGFENPLSSVNEIETKLSALLGSETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKI
IDEQDVPTHILSKLTFTLRNHPEYLEASVLSPDDVRQVLSMDF
Download Length: 372 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|