Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1894595..1895214 Replicon chromosome
Accession NZ_CP102374
Organism Pseudomonas sp. T8

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NRG23_RS08255 Protein ID WP_124301294.1
Coordinates 1894595..1894777 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NRG23_RS08260 Protein ID WP_092418556.1
Coordinates 1894813..1895214 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRG23_RS08240 (NRG23_08240) 1892728..1893282 + 555 WP_257374342.1 hypothetical protein -
NRG23_RS08245 (NRG23_08245) 1893267..1893623 + 357 WP_257374343.1 hypothetical protein -
NRG23_RS08250 (NRG23_08250) 1894024..1894305 + 282 WP_257374344.1 hypothetical protein -
NRG23_RS08255 (NRG23_08255) 1894595..1894777 + 183 WP_124301294.1 type II toxin-antitoxin system HicA family toxin Toxin
NRG23_RS08260 (NRG23_08260) 1894813..1895214 + 402 WP_092418556.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NRG23_RS08265 (NRG23_08265) 1896091..1896855 - 765 WP_257374345.1 hypothetical protein -
NRG23_RS08270 (NRG23_08270) 1896949..1897584 - 636 WP_124301293.1 response regulator transcription factor -
NRG23_RS08275 (NRG23_08275) 1897581..1899470 - 1890 WP_257374346.1 PAS domain S-box protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1880081..1903171 23090


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6827.99 Da        Isoelectric Point: 11.1724

>T253483 WP_124301294.1 NZ_CP102374:1894595-1894777 [Pseudomonas sp. T8]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPRKDLPRGTVRAIQKLAGLI

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14588.55 Da        Isoelectric Point: 4.7465

>AT253483 WP_092418556.1 NZ_CP102374:1894813-1895214 [Pseudomonas sp. T8]
VHYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References