Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 926053..926545 Replicon chromosome
Accession NZ_CP102137
Organism Streptococcus suis strain M104300_S20

Toxin (Protein)


Gene name relE Uniprot ID D5AHJ6
Locus tag NQZ96_RS04515 Protein ID WP_011922404.1
Coordinates 926053..926310 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AHJ7
Locus tag NQZ96_RS04520 Protein ID WP_012775104.1
Coordinates 926294..926545 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQZ96_RS04495 (NQZ96_04495) 921687..922757 + 1071 WP_012775101.1 tyrosine recombinase XerS -
NQZ96_RS04500 (NQZ96_04500) 922827..924335 - 1509 WP_011922400.1 phosphomannomutase/phosphoglucomutase -
NQZ96_RS04505 (NQZ96_04505) 924411..925352 - 942 WP_012775102.1 sensor histidine kinase -
NQZ96_RS04510 (NQZ96_04510) 925349..926014 - 666 WP_012775103.1 response regulator transcription factor -
NQZ96_RS04515 (NQZ96_04515) 926053..926310 - 258 WP_011922404.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NQZ96_RS04520 (NQZ96_04520) 926294..926545 - 252 WP_012775104.1 DUF6290 family protein Antitoxin
NQZ96_RS04525 (NQZ96_04525) 926637..928607 - 1971 WP_012775105.1 FtsX-like permease family protein -
NQZ96_RS04530 (NQZ96_04530) 928608..929360 - 753 WP_011922409.1 ABC transporter ATP-binding protein -
NQZ96_RS04535 (NQZ96_04535) 929496..930230 - 735 WP_011922410.1 ABC transporter permease -
NQZ96_RS04540 (NQZ96_04540) 930232..930978 - 747 WP_011922411.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-75)

Antitoxin

Protein of unknown function DUF6290

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9981.62 Da        Isoelectric Point: 10.8924

>T253212 WP_011922404.1 NZ_CP102137:c926310-926053 [Streptococcus suis]
MKTCYKLVPTSRFIKQLKKLDKFTQKQITNYLSSHVTDNPRQYGKALTANRSGQWRYRIGNYRVIVNIEDDKLIVTSIKM
RNGSI

Download         Length: 258 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9325.59 Da        Isoelectric Point: 3.7666

>AT253212 WP_012775104.1 NZ_CP102137:c926545-926294 [Streptococcus suis]
MAAITLKVSEQDKLFMQAMAKFEGVSLSELIRTKTLEALEDEYDARVADIALSEYEADLAKGIEPISWEEMLEELGLTDE
DLL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8U747

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z9GU89

References