Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2998495..2998966 Replicon chromosome
Accession NZ_CP101925
Organism Escherichia coli strain Seattle 1946

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag NP429_RS14545 Protein ID WP_001303511.1
Coordinates 2998688..2998966 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag NP429_RS14540 Protein ID WP_001302048.1
Coordinates 2998495..2998686 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP429_RS14495 (2993744) 2993744..2993962 - 219 WP_000209148.1 DUF4014 family protein -
NP429_RS14500 (2993995) 2993995..2994207 - 213 WP_000072553.1 hypothetical protein -
NP429_RS14505 (2994313) 2994313..2994735 - 423 Protein_2848 DUF977 family protein -
NP429_RS14510 (2994751) 2994751..2995521 - 771 WP_000450998.1 DUF1627 domain-containing protein -
NP429_RS14515 (2995543) 2995543..2996289 - 747 WP_000788950.1 ATP-binding protein -
NP429_RS14520 (2996296) 2996296..2997258 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
NP429_RS14525 (2997281) 2997281..2997706 - 426 WP_000693943.1 toxin YdaT family protein -
NP429_RS14530 (2997703) 2997703..2998005 - 303 WP_001556930.1 transcriptional regulator -
NP429_RS14535 (2998103) 2998103..2998474 + 372 WP_001169687.1 hypothetical protein -
NP429_RS14540 (2998495) 2998495..2998686 + 192 WP_001302048.1 hypothetical protein Antitoxin
NP429_RS14545 (2998688) 2998688..2998966 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NP429_RS14550 (2999258) 2999258..2999410 + 153 WP_000380313.1 DUF1391 family protein -
NP429_RS14555 (2999422) 2999422..2999760 + 339 WP_000394541.1 hypothetical protein -
NP429_RS14560 (2999749) 2999749..2999943 - 195 WP_001295058.1 hypothetical protein -
NP429_RS14565 (3000519) 3000519..3000707 + 189 WP_000449175.1 cell division inhibition protein DicB -
NP429_RS14570 (3000704) 3000704..3000892 + 189 WP_000199475.1 DUF1482 family protein -
NP429_RS14575 (3000985) 3000985..3003423 + 2439 WP_000102132.1 exonuclease -
NP429_RS14580 (3003485) 3003485..3003754 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2981098..3008149 27051


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T252998 WP_001303511.1 NZ_CP101925:2998688-2998966 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT252998 WP_001302048.1 NZ_CP101925:2998495-2998686 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References