Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3952354..3953014 Replicon chromosome
Accession NZ_CP101907
Organism Salmonella enterica subsp. enterica strain QA-1986 973

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NP441_RS19435 Protein ID WP_000244756.1
Coordinates 3952601..3953014 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NP441_RS19430 Protein ID WP_000351186.1
Coordinates 3952354..3952620 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NP441_RS19410 (3948283) 3948283..3949716 - 1434 WP_001230140.1 6-phospho-beta-glucosidase BglA -
NP441_RS19415 (3949874) 3949874..3950185 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NP441_RS19420 (3950349) 3950349..3951008 + 660 WP_000250289.1 hemolysin III family protein -
NP441_RS19425 (3951124) 3951124..3952104 - 981 WP_058652990.1 tRNA-modifying protein YgfZ -
NP441_RS19430 (3952354) 3952354..3952620 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NP441_RS19435 (3952601) 3952601..3953014 + 414 WP_000244756.1 protein YgfX Toxin
NP441_RS19440 (3953067) 3953067..3953588 - 522 WP_001055885.1 flavodoxin FldB -
NP441_RS19445 (3953701) 3953701..3954597 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NP441_RS19450 (3954621) 3954621..3955334 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NP441_RS19455 (3955340) 3955340..3957073 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T252875 WP_000244756.1 NZ_CP101907:3952601-3953014 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT252875 WP_000351186.1 NZ_CP101907:3952354-3952620 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References