Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2356124..2357382 Replicon chromosome
Accession NZ_CP101885
Organism Pseudomonas aeruginosa strain M27432

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag NOQ96_RS11415 Protein ID WP_003086331.1
Coordinates 2356627..2357382 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag NOQ96_RS11410 Protein ID WP_003086329.1
Coordinates 2356124..2356492 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOQ96_RS11390 (NOQ96_11390) 2352287..2352562 + 276 WP_023098713.1 zinc ribbon domain-containing protein -
NOQ96_RS11395 (NOQ96_11395) 2352565..2353041 - 477 WP_003086322.1 hypothetical protein -
NOQ96_RS11400 (NOQ96_11400) 2353120..2354709 + 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
NOQ96_RS11405 (NOQ96_11405) 2354765..2356051 + 1287 WP_003086327.1 FAD-binding oxidoreductase -
NOQ96_RS11410 (NOQ96_11410) 2356124..2356492 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
NOQ96_RS11415 (NOQ96_11415) 2356627..2357382 + 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
NOQ96_RS11420 (NOQ96_11420) 2358152..2359513 + 1362 WP_003081943.1 DNA recombination protein RmuC -
NOQ96_RS11425 (NOQ96_11425) 2359668..2362211 - 2544 WP_003134033.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T252856 WP_003086331.1 NZ_CP101885:2356627-2357382 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT252856 WP_003086329.1 NZ_CP101885:2356124-2356492 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References