Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2664942..2666530 Replicon chromosome
Accession NZ_CP101790
Organism Klebsiella pneumoniae strain hvKP859

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NPJ86_RS13035 Protein ID WP_040211308.1
Coordinates 2664942..2666264 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NPJ86_RS13040 Protein ID WP_040216240.1
Coordinates 2666264..2666530 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NPJ86_RS13020 (NPJ86_13020) 2659999..2662500 + 2502 WP_130940394.1 fimbria/pilus outer membrane usher protein -
NPJ86_RS13025 (NPJ86_13025) 2662488..2663492 + 1005 WP_021462558.1 fimbrial protein -
NPJ86_RS13030 (NPJ86_13030) 2663633..2664925 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NPJ86_RS13035 (NPJ86_13035) 2664942..2666264 - 1323 WP_040211308.1 type II toxin-antitoxin system HipA family toxin Toxin
NPJ86_RS13040 (NPJ86_13040) 2666264..2666530 - 267 WP_040216240.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NPJ86_RS13045 (NPJ86_13045) 2666916..2667242 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NPJ86_RS13050 (NPJ86_13050) 2667239..2667739 - 501 WP_023285113.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NPJ86_RS13055 (NPJ86_13055) 2667717..2669096 - 1380 WP_073557772.1 nucleobase:cation symporter-2 family protein -
NPJ86_RS13060 (NPJ86_13060) 2669442..2670596 + 1155 WP_117024249.1 FAD-dependent urate hydroxylase HpxO -
NPJ86_RS13065 (NPJ86_13065) 2670577..2671500 - 924 WP_073557774.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2472756..2709119 236363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49099.40 Da        Isoelectric Point: 7.8897

>T252725 WP_040211308.1 NZ_CP101790:c2666264-2664942 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARGLGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9959.39 Da        Isoelectric Point: 8.6103

>AT252725 WP_040216240.1 NZ_CP101790:c2666530-2666264 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DHNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References