Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 683042..683661 Replicon chromosome
Accession NZ_CP101752
Organism Pseudomonas citronellolis strain C12

Toxin (Protein)


Gene name hicA Uniprot ID W5J3G4
Locus tag NOX82_RS03030 Protein ID WP_009615522.1
Coordinates 683042..683224 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID W5J3H2
Locus tag NOX82_RS03035 Protein ID WP_009615524.1
Coordinates 683257..683661 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOX82_RS03020 (NOX82_03020) 681620..681778 + 159 WP_009615518.1 YqaE/Pmp3 family membrane protein -
NOX82_RS03025 (NOX82_03025) 682095..682583 - 489 WP_058073292.1 Bro-N domain-containing protein -
NOX82_RS03030 (NOX82_03030) 683042..683224 + 183 WP_009615522.1 type II toxin-antitoxin system HicA family toxin Toxin
NOX82_RS03035 (NOX82_03035) 683257..683661 + 405 WP_009615524.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NOX82_RS03040 (NOX82_03040) 684002..684184 + 183 WP_058073290.1 type II toxin-antitoxin system HicA family toxin -
NOX82_RS03045 (NOX82_03045) 684213..684635 + 423 WP_058073289.1 helix-turn-helix domain-containing protein -
NOX82_RS03050 (NOX82_03050) 684660..685430 - 771 WP_249917986.1 NERD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6962.13 Da        Isoelectric Point: 12.2993

>T252594 WP_009615522.1 NZ_CP101752:683042-683224 [Pseudomonas citronellolis]
MRSREIMELIRADGWFLVEVKGSHHQFRHFTKKGRVTVPHPRSNLPIGTVNSILRQAGLR

Download         Length: 183 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14532.23 Da        Isoelectric Point: 4.5714

>AT252594 WP_009615524.1 NZ_CP101752:683257-683661 [Pseudomonas citronellolis]
MKFPVVLHKDADSDYGVTIPDVPGCFSAGGTVSQALENVQEALALHFEGLVADGETLPQAQEVDTHMGNPDYAGGVWAVV
DFDVTPYLGKAVRFNASLPENLLQRIDERVKRDHRYASRSGFLATAALRELSSN

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A127MLP4

Antitoxin

Source ID Structure
AlphaFold DB A0A1A5CY34

References