25251

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 940193..940883 Replicon chromosome
Accession NC_015566
Organism Serratia sp. AS12

Toxin (Protein)


Gene name tad Uniprot ID A0A7U3YZ62
Locus tag SERAS12_RS04325 Protein ID WP_013811601.1
Coordinates 940509..940883 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID A0A7U3YZ40
Locus tag SERAS12_RS04320 Protein ID WP_013811600.1
Coordinates 940193..940522 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SERAS12_RS04300 936090..937550 - 1461 WP_004948989.1 NCS1 family nucleobase:cation symporter-1 -
SERAS12_RS04305 937717..938466 + 750 WP_013811597.1 GntR family transcriptional regulator -
SERAS12_RS04310 938463..939206 + 744 WP_013811598.1 allantoin racemase -
SERAS12_RS04315 939226..940164 + 939 WP_013811599.1 allantoinase PuuE -
SERAS12_RS04320 940193..940522 - 330 WP_013811600.1 helix-turn-helix domain-containing protein Antitoxin
SERAS12_RS04325 940509..940883 - 375 WP_013811601.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SERAS12_RS04330 940989..943184 - 2196 WP_013811602.1 TonB-dependent siderophore receptor -
SERAS12_RS04335 943220..944548 - 1329 WP_013811603.1 lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(16-95)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14031.35 Da        Isoelectric Point: 9.8478

>T25251 WP_013811601.1 NC_015566:c940883-940509 [Serratia sp. AS12]
MDKHQVKQLIWIASSKKDLLSLPEEIIKSMGYTLHWVQAGLTPPGVNPLKGFLGAGVLEKVEDFDGNTYRAVYTVRFEDT
VFVLHCFQKKSKTGISTPKADIEFIKSRLSKAKQIYEDMKNGKI

Download         Length: 375 bp

>T25251 NC_015566:c940883-940509 [Serratia sp. AS12]
ATGGATAAGCACCAAGTAAAACAGCTGATATGGATAGCAAGCAGTAAAAAAGACCTGCTTTCGCTGCCTGAAGAAATTAT
TAAATCAATGGGTTATACCCTACATTGGGTTCAGGCGGGATTAACGCCACCCGGAGTGAACCCCTTAAAGGGATTTCTGG
GTGCTGGCGTATTGGAAAAGGTTGAGGATTTTGACGGTAACACCTACCGGGCAGTTTATACCGTGCGGTTCGAAGACACT
GTATTTGTGCTCCACTGCTTTCAGAAAAAATCCAAAACAGGAATTTCAACGCCAAAGGCGGACATTGAATTCATCAAGTC
TCGCCTGAGCAAAGCCAAACAGATTTACGAGGACATGAAAAATGGCAAAATATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12261.17 Da        Isoelectric Point: 6.3033

>AT25251 WP_013811600.1 NC_015566:c940522-940193 [Serratia sp. AS12]
MAKYDENDFEIGSDNIFADLKLPDAENLKLKADLAIKIINTIQQLGLNQVEAGKRMNLPQARVSALYNGKFFNMSEQKLM
ICLNRLGYDIEIIVKPSQNTVGQRTLSVT

Download         Length: 330 bp

>AT25251 NC_015566:c940522-940193 [Serratia sp. AS12]
ATGGCAAAATATGACGAAAATGATTTTGAGATCGGTTCGGACAACATTTTTGCTGATTTAAAACTGCCTGATGCAGAAAA
CCTTAAACTAAAGGCCGATCTCGCCATCAAAATTATCAATACAATTCAACAGCTAGGACTCAACCAAGTAGAAGCGGGCA
AACGAATGAACCTGCCACAGGCACGAGTTTCCGCGTTGTATAACGGCAAATTTTTCAATATGTCAGAGCAAAAGCTGATG
ATCTGCCTCAACCGACTCGGTTACGACATAGAAATTATCGTCAAACCCAGCCAGAACACCGTCGGCCAGCGTACCCTTTC
AGTGACGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U3YZ62

Antitoxin

Source ID Structure
AlphaFold DB A0A7U3YZ40

References