Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3057266..3057878 Replicon chromosome
Accession NZ_CP101666
Organism Escherichia coli strain M171-1

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag NO473_RS14870 Protein ID WP_000833473.1
Coordinates 3057266..3057451 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5F1W1Z0
Locus tag NO473_RS14875 Protein ID WP_000499743.1
Coordinates 3057468..3057878 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NO473_RS14855 (3053001) 3053001..3053969 + 969 Protein_2884 L-threonine dehydrogenase -
NO473_RS14860 (3054134) 3054134..3055672 + 1539 WP_001359414.1 aldehyde dehydrogenase AldB -
NO473_RS14865 (3055713) 3055713..3056792 - 1080 WP_170854857.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
NO473_RS14870 (3057266) 3057266..3057451 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
NO473_RS14875 (3057468) 3057468..3057878 + 411 WP_000499743.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NO473_RS14880 (3057950) 3057950..3059914 - 1965 WP_040062336.1 glycoside hydrolase family 127 protein -
NO473_RS14885 (3059925) 3059925..3061325 - 1401 WP_000204832.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3051942..3052865 923


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T252469 WP_000833473.1 NZ_CP101666:3057266-3057451 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15213.09 Da        Isoelectric Point: 4.5486

>AT252469 WP_000499743.1 NZ_CP101666:3057468-3057878 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGA

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A5F1W1Z0

References